Comparing melatonin and lidocaine to reduce postoperative delirium in elderly hip surgery patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of oral melatonin versus intraoperative lidocaine infusion in reducing the incidence of postoperative delirium in elderly patients undergoing total hip arthroplasty under spinal anesthesia. Delirium is a common complication in this demographic, with prevalence rates ranging from 20% to 45%. The study will involve elderly patients aged over 65 with specific inclusion and exclusion criteria, assessing the impact of these interventions on their cognitive outcomes post-surgery. The research will provide insights into potential preventive measures for postoperative delirium in high-risk surgical patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Elderly patients aged \>65 years old undergoing unilateral total hip arthroplasty.
* Patients with body mass index (BMI) (18-30) kg/m2.
* American Society of Anesthesiologists (ASA) physical status I-III, scheduled to undergo unilateral total hip arthroplasty.

Exclusion Criteria:

* History of mental illness or scoring less than 8 using abbreviated mental test (AMT) before operation.
* Obvious sinus bradycardia (heart rate of \<50 beats per minute) or other serious cardiovascular diseases.
* Symptomatic cerebrovascular disease (such as previous stroke).
* History of liver and kidney dysfunction.
* Allergy to lidocaine or melatonin.
* Metabolic disorders and fluid, electrolytes disturbances.
* Alcohol dependence or drug abuse.
* Redo surgery or infectious complications.
* CNS medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).
* History of deep vein thrombosis.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Alshaimaa S Alasrag, Master
• Email: alshaimaa.alasrag@med.tanta.edu.eg
• Phone: 00201018940354

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.