Comparing medical grade honey to Fluconazole for treating recurrent vaginal yeast infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a medical grade honey formulation (L-Mesitran) compared to Fluconazole in treating recurrent vulvovaginal candidiasis. Participants will undergo vaginal swabs to assess the presence of Candida after one month of treatment, with follow-ups at six and twelve months to monitor symptoms and potential relapses. The study will also collect data on side effects, discomfort, and quality of life to provide a comprehensive understanding of treatment outcomes. A total of 252 patients will be included in the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women of at least 18 years old
* Recurrent vulvovaginal candidiasis (At least 3 episodes of clinical symptoms during the last year)
* Clinical and microbiological diagnosis of (recurrent) vulvovaginal candidiasis at time of consultation
* Capacity to understand, consent, and comply with the trial procedures

Exclusion Criteria:

* Mixed vaginal infections
* Pregnancy or the intention to become pregnant during the study period
* Women using systemic or topical antifungal medication during the last 2 weeks prior to inclusion
* Known allergies or contra-indications for Fluconazole or honey
* Candida with resistance for Fluconazole
* Women giving breastfeeding

Where it's running

• Zuyderland Medical Centre
  Heerlen, Netherlands Recruiting
• MaastrichtUMC
  Maastricht, Netherlands Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Biweekly long-term Ocfidiofungin for recurrent vulvovaginal candidiasis in women

  This study tests whether OCF001 intravaginal gel can safely and effectively reduce symptoms and recurrence in women with vulvovaginal candidiasis compared with a placebo.

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• Bioithas WOMAN as an added treatment for vulvovaginal candidiasis

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• Vaginal cooling device for treating vulvovaginal yeast infections

  This tests a vaginal cooling device to see if it helps women aged 22–49 with vulvovaginal yeast infections feel better and clear the infection.

  Recruiting at 8 sites Coologics, Inc · Jacksonville, Florida and 9 other locations · NCT06983041

• Comparing Clotrimazole with and without Lactulose for treating vaginal yeast infections in women

  This study is testing if adding Lactulose to Clotrimazole can help women with vaginal yeast infections feel better and recover faster compared to using Clotrimazole alone.

  Recruiting at 7 sites Phase 2/3 AVVA Pharmaceuticals Ltd. · Minsk, Minsk City and 6 other locations · NCT06835361

• Using a multi-strain probiotic to reduce recurrent vulvovaginal candidiasis

  This study is testing if a special probiotic can help women aged 18-50 with frequent yeast infections feel better and have fewer episodes.

  Recruiting at 6 sites The Archer-Daniels-Midland Company · Vadodara, Gujarat and 5 other locations · NCT06480604

• Evaluating the safety of ibrexafungerp in pregnant women and their infants

  This study is testing whether ibrexafungerp is safe for pregnant women and their babies by looking at their health during and after pregnancy.

  Recruiting GlaxoSmithKline · New Delhi, Vasant Vihar · NCT05908682

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.