Comparing Mannitol and Polyethylene Glycol for Better Bowel Preparation
Effectiveness of 1L Mannitol Versus 1L Polyethylene Glycol Electrolyte Dispersion as a Salve for Patients With Inadequate Bowel Preparation: a Randomized Controlled Clinical Trial
This study tests whether a new drink called mannitol can help people prepare better for a colonoscopy compared to the usual drink, polyethylene glycol (PEG), to see if it makes the process easier and more effective.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 134 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Ningbo No. 1 Hospital Academic / other |
| Locations | 1 site (Ningbo, Zhejiang) |
| Trial ID | NCT05912114 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of mannitol versus polyethylene glycol (PEG) electrolyte dispersion in improving bowel preparation for patients undergoing colonoscopy. It aims to address the issue of inadequate bowel cleansing, which can lead to rescheduling procedures. The study focuses on patient compliance, as mannitol is expected to be more palatable and easier to take than PEG, potentially leading to better outcomes. Participants will be randomized to receive either mannitol or PEG before their colonoscopy.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-75 with inadequate bowel cleanliness prior to their first colonoscopy.
Not a fit: Patients who are pregnant, have a history of colorectal surgery, or have severe medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved bowel preparation methods, enhancing patient compliance and outcomes for colonoscopy procedures.
How similar studies have performed: Previous studies have shown that oral PEG is effective, but this approach using mannitol is relatively novel and untested in this specific context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18-75 years with a pre-first colonoscopy bowel cleanliness of less than 2 points in any segment of the bowel. Exclusion Criteria: - (1) Pregnant women. (2) History of colorectal surgery. (3) Patients with acute exacerbation of inflammatory bowel disease. (4) Patients with severe medical conditions that make them unsuitable for colonoscopy. (5) Patients with known allergy to mannitol/PEG. (6) Patients who refuse to sign the informed consent form.
Where this trial is running
Ningbo, Zhejiang
- Ningbo first hospital — Ningbo, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Lei f Xu
- Email: xulei22@163.com
- Phone: +8613486659126
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.