Comparing mannitol and iohexol for measuring kidney function
Comparison of Two Different External Clearance Markers for Measuring Glomerular Filtration Rate (GFR) - Mannitol and Iohexol, in Patients Treated in the Intensive Care Units and in Outpatients With Chronic Kidney Disease.
This study is testing whether mannitol is as good as iohexol for measuring kidney function in patients with acute kidney injury and chronic kidney disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 1 site (Gothenburg) |
| Trial ID | NCT06238310 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of two different external clearance markers, mannitol and iohexol, in measuring glomerular filtration rate (GFR) in patients with acute kidney injury and chronic kidney disease. The study will include patients in intensive care units and an outpatient group, focusing on those with stable circulatory parameters. By evaluating the reliability of mannitol as a new marker against the standard iohexol, the trial seeks to improve GFR measurement methods, which are crucial for managing kidney function in critically ill patients. The outcomes will be assessed using statistical methods to determine the accuracy of both markers.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with acute or acute on chronic kidney failure being treated in intensive care units or stable chronic kidney disease patients in outpatient settings.
Not a fit: Patients with unstable circulation requiring fluid resuscitation or those with known allergies to contrast material will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a safer and more reliable method for measuring kidney function in critically ill patients.
How similar studies have performed: While the use of iohexol is standard, the comparison with mannitol is a novel approach that has not been extensively tested in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with acute or acute on chronic kidney failure (AKI, CKD) on intensive care units because of any kind of organ insufficiency. * Stabile circulatory parameters. * CKD-patients in outpatient group Exclusion Criteria: * unstable circulation with need for fluid resuscitation. * known extracellular volume expansion as ascites or peripheral edema. * Intravenous paracetamol administration between or during the measurement period. * measurement with iohexol during the previous days. * missing inform consent.
Where this trial is running
Gothenburg
- SahlgrenskaUH — Gothenburg, Sweden (Recruiting)
Study contacts
- Study coordinator: Katalin Kiss
- Email: katalin_kiss@icloud.com
- Phone: +46761285184
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.