Comparing lung function and exercise ability in children with hemophilia and healthy peers
Comparison of Pulmonary Function, Exercise Capacity, and Physical Activity Level Between Children with Hemophilia and Healthy Controls
This study looks at how hemophilia affects lung function and exercise ability in children compared to their healthy peers to better understand the importance of physical activity for them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 8 Years to 18 Years |
| Sex | All |
| Sponsor | Hacettepe University Academic / other |
| Locations | 1 site (Ankara) |
| Trial ID | NCT06636565 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare pulmonary function, exercise capacity, posture, and physical activity levels between children diagnosed with hemophilia and healthy controls. It focuses on understanding how hemophilia affects physical activity and respiratory mechanics, which may be influenced by chronic pain and joint issues. The study will involve children aged 8-18 who are clinically stable and on prophylaxis treatment, assessing their ability to cooperate with various tests. The findings could provide insights into the importance of exercise for children with hemophilia.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 8-18 with a diagnosis of hemophilia who are clinically stable and on prophylaxis treatment.
Not a fit: Patients who are inhibitor positive, have a history of acute joint or intramuscular bleeding, or severe cardiovascular, orthopedic, or neurological issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the physical capabilities of children with hemophilia, potentially leading to improved management and encouragement of physical activity.
How similar studies have performed: While there may be limited studies directly comparing these specific parameters in children with hemophilia, the approach of assessing exercise capacity and pulmonary function is supported by existing literature on the benefits of physical activity in chronic conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Hemophilia group Inclusion criteria: * Having been diagnosed with hemophilia and being clinically stable, * Being between the ages of 8-18, * Being on prophylaxis treatment (a routine treatment), * Being 125 cm or taller, * Being inhibitor negative at the time of enrollment, * To be able to cooperate with the tests to be performed, * Being willing to participate in the study. Exclusion criteria: * Being inhibitor positive at the time of enrollment, * Having a history of acute joint bleeding, * Being unable to bear weight on the extremities, * Having a history of acute intramuscular bleeding, * Having undergone radionuclide synovectomy, * Having a history of surgery on any of the lower extremity joints, * Having a severe cardiovascular, orthopedic or neurological problem that may affect the assessments. Control group Inclusion criteria: * Not having any known internal or chronic disease * Being male between the ages of 8-18 * Having full range of motion in the upper extremity * Having full range of motion in the lower extremity * Not having any history of injury or surgery in the lower extremity * Being 125 cm or taller * Being willing to participate in the study Exclusion criteria: * Having any problem that may affect the tests * Not having full range of motion in the upper extremity * Having a history of injury or surgery in any of the lower extremity joints * Having a neurological deficit * Having pain or movement limitation in the lower extremity
Where this trial is running
Ankara
- Hacettepe University Faculty of Physical Therapy and Rehabilitation — Ankara, Turkey (Recruiting)
Study contacts
- Principal investigator: Aslihan Cakmak-Onal, PhD, PT — Hacettepe University
- Study coordinator: Aslihan Cakmak-Onal, PhD, PT
- Email: aslihancakmak90@gmail.com
- Phone: +90 312 305 1576
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.