Comparing low dose rosuvastatin with ezetimibe to high dose rosuvastatin in heart attack patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of a combination therapy using low dose rosuvastatin (5mg) and ezetimibe (10mg) compared to high dose rosuvastatin (20mg) in patients who have experienced an acute myocardial infarction and undergone percutaneous coronary intervention. The goal is to determine if the combination therapy can achieve similar reductions in LDL cholesterol levels and decrease major adverse cardiac events. The study builds on previous findings that link LDL cholesterol reduction to heart disease risk, aiming to provide a potentially safer alternative to high-dose statin therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults Aged 19 and up
2. Patients diagnosed with myocardial infarction (both ST segment elevation and non-ST segment elevation) who were treated with percutaneous coronary intervention (Myocardial infarction defined as in the 4th Universal Definition of Myocardial Infarction)
3. For female patients who are of childbearing age, subjects that agreed on taking mandatory pregnancy test
4. Patients who agreed and signed on the informed consent form

Exclusion Criteria:

1. Patients with life expectancy of a year or less due to malignancy
2. Patients with chronic liver disease
3. Patients with sensitivity to active ingredient of the research drugs (ezetimibe and/or rosuvastatin) or patients who are prohibited to take ezetimibe and/or rosuvastatin.
4. Pregnant and/or breastfeeding
5. Female patients who are unable to use any means of contraception
6. Patients receiving hemodialysis, peritoneal dialysis patients and/or kidney transplant patients, due to end stage renal disease
7. Patients who participated in other clinical trial(s) within 3 months from the screening (except non-interventional observational study)
8. Patients considered inappropriate for the study for any other reason(s) by the inspector(s)

Where it's running

• Bucheon St.Mary Hospital
  Bucheon-si, Gyeonggido, South Korea Recruiting
• St.Vincent's Hospital
  Suwon, Gyeonggido, South Korea Recruiting
• Uijeongbu St.Mary's Hospital
  Uijeongbu-si, Gyeonggido, South Korea Recruiting
• Daejeon St.Mary's Hospital
  Daejeon, South Korea Recruiting
• Incheon St.Mary's Hospital
  Incheon, South Korea Recruiting
• Seoul St.Mary's Hospital
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Kiyuk Chang, MD,PhD
• Email: kiyuk@catholic.ac.kr
• Phone: 82-10-9175-2076

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.