Comparing LOT-CRT and conventional BiVP in heart failure patients with intraventricular block

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial is designed to compare the effectiveness of left bundle branch area pacing (LOT-CRT) against conventional biventricular pacing (BiVP) in patients suffering from chronic heart failure with intraventricular block. The study will enroll 83 patients over a three-year period and will follow them for at least six months to assess improvements in left ventricular systolic function. By utilizing a randomized controlled approach, the trial aims to provide insights into the potential advantages of LOT-CRT in this specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Ischemic or non ischemic cardiomyopathy
2. Optimal medical therapy for at lest 3 months
3. NYHA class II-IV
4. LVEF≤35% as assessed by echocardiography
5. Sinus rhythm (may have paroxysmal atrial fibrillation)
6. QRS duration ≥ 150ms
7. Intraventricular block (NICD), QRS morphology is neither LBBB nor RBBB

Exclusion Criteria:

1. Valvular heart disease that requires or has undergone surgical intervention
2. After mechanical tricuspid valve replacement
3. Persistent or permanent atrial fibrillation or atrial flutter
4. Second or third degree atrioventricular block
5. Have a history of acute myocardial infarction within 3 months prior to enrollment
6. Patient's expected survival time is less than 12 months
7. Pregnant or planned to conceive
8. Ventricular septal hypertrophy (ventricular septal thickness exceeds 15mm at the end of diastole)
9. Patients with simple and persistent left superior vena cava
10. Patients with existing pacemaker implantation

Where it's running

• The First Affiliated Hospital with Nanjing Medical University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Jiangang Zou — The First Affiliated Hospital with Nanjing Medical University
• Study coordinator: Jiangang Zou
• Email: jgzou@njmu.edu.cn
• Phone: 86-13605191407

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.