Comparing light therapy and probiotics for treating bad breath

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) combined with probiotics in treating halitosis, a condition characterized by bad breath. A total of 92 participants aged 18 to 60 with diagnosed halitosis will be randomly assigned to one of four treatment groups, including a control group and groups receiving various combinations of oral hygiene practices, aPDT, and probiotic lozenges. The aim is to determine if the addition of probiotics enhances the effectiveness of aPDT in reducing halitosis symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of halitosis showing sulfhydride (SH2) ≥ 112 ppb in gas chromatography.

Exclusion Criteria:

* Individuals with dentofacial anomalies (such as cleft lip, cleft palate and nasopalatine);
* Undergoing orthodontic and/or orthopedic treatment;
* Undergoing oncological treatment;
* With systemic alterations (gastrointestinal, renal, hepatic)
* Undergoing antibiotic treatment up to 1 month before the research;
* Pregnant women.

Where it's running

• Nove de Julho University
  São Paulo, São Paulo, Brazil Recruiting

Study contacts

• Study coordinator: Sandra K Bussadori
• Email: pesquisa@uninove.br
• Phone: +55 11 2633-9000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• SALI-10 probiotic lozenges for gingivitis and halitosis

  This study tests whether SALI-10 probiotic lozenges can help people with gingivitis and bad breath.

  Recruiting Ostia Sciences · Hamilton, Ontario · NCT07508839

• Adding laser-based antimicrobial therapy to deep cleaning and tongue scraping for bad breath in people with type 2 diabetes and severe gum disease

  This trial tests whether adding antimicrobial photodynamic therapy to standard deep cleaning and tongue scraping reduces bad breath in people with type 2 diabetes and advanced periodontitis.

  Recruiting University of Sao Paulo · Bauru, São Paulo · NCT07463859

• Using kefir mouthwash to improve oral health

  This study is testing if using kefir mouthwash can help young adults with gum inflammation improve their oral health compared to a standard mouthwash.

  Recruiting Phase 2/3 Al-Mustansiriyah University · Baghdad · NCT06900881

• Using resveratrol mouthwash to reduce bad breath in dental students

  This study is testing if a mouthwash with resveratrol can help dental students reduce bad breath caused by certain bacteria.

  Recruiting Phase 3 Al-Mustansiriyah University · Baghdad, Bab Al-Moadham · NCT06882564

• Adding tongue scraping to initial periodontal therapy to reduce bad breath

  This will see if adding daily tongue scraping to standard initial periodontal treatment reduces bad breath in adults with generalized periodontitis.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT06091228

• Aquamin® for reducing bad breath in adults

  This study tests whether Aquamin®, a multi-mineral product from red marine algae, can reduce halitosis after 90 days in adults who report bad breath.

  Recruiting Phase 2 University of Michigan · Ann Arbor, Michigan · NCT05058638

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.