Comparing light therapy and probiotics for treating bad breath
Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the Treatment of Halitosis - Controlled Randomized Clinical Trial
PHASE1 · University of Nove de Julho · NCT06583720
This study is testing whether combining light therapy with probiotics can help people with bad breath feel fresher compared to other treatments.
Quick facts
| Phase | PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 92 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | University of Nove de Julho (other) |
| Locations | 1 site (São Paulo, São Paulo) |
| Trial ID | NCT06583720 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) combined with probiotics in treating halitosis, a condition characterized by bad breath. A total of 92 participants aged 18 to 60 with diagnosed halitosis will be randomly assigned to one of four treatment groups, including a control group and groups receiving various combinations of oral hygiene practices, aPDT, and probiotic lozenges. The aim is to determine if the addition of probiotics enhances the effectiveness of aPDT in reducing halitosis symptoms.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 60 diagnosed with halitosis and exhibiting specific sulfhydride levels.
Not a fit: Patients with dentofacial anomalies, systemic health issues, or those currently undergoing certain treatments may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the management of halitosis, providing patients with a more effective solution.
How similar studies have performed: While there is limited data on this specific combination of treatments, similar approaches using probiotics and light therapy have shown promise in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of halitosis showing sulfhydride (SH2) ≥ 112 ppb in gas chromatography. Exclusion Criteria: * Individuals with dentofacial anomalies (such as cleft lip, cleft palate and nasopalatine); * Undergoing orthodontic and/or orthopedic treatment; * Undergoing oncological treatment; * With systemic alterations (gastrointestinal, renal, hepatic) * Undergoing antibiotic treatment up to 1 month before the research; * Pregnant women.
Where this trial is running
São Paulo, São Paulo
- Nove de Julho University — São Paulo, São Paulo, Brazil (RECRUITING)
Study contacts
- Study coordinator: Sandra K Bussadori
- Email: pesquisa@uninove.br
- Phone: +55 11 2633-9000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Halitosis