Comparing Lidocaine and Levobupivacaine for Sciatic Nerve Block in Foot Surgery
Official title: A Prospective Randomized Comparison of the Effects of Lidocaine and Levobupivacaine on Block Dynamics After a Subparaneural Popliteal Sciatic Nerve Block
Run by Chinese University of Hong Kong · NCT04397484 · Data updated 2026-11-12
This study is testing which of two local anesthetics, Lidocaine or Levobupivacaine, works better for numbing the leg during foot surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Shatin, New Territories) |
| Status | Recruiting |
| Started | September 20, 2023 |
| Main results expected | September 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT04397484 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults scheduled for elective forefoot surgery with an ASA physical status of I-III.
✕Probably not a fit
Patients with ASA physical status greater than III, pregnancy, or allergies to local anesthetics may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effectiveness of two local anesthetics, Lidocaine and Levobupivacaine, in performing ultrasound-guided subparaneural popliteal sciatic nerve blocks for patients undergoing elective forefoot surgery. The study will enroll 40 patients and assess the block dynamics, including onset time and duration of anesthesia. By evaluating the differences in block performance between the two anesthetics, the trial seeks to identify the optimal choice for regional anesthesia in this surgical context.
Why it matters
Potential benefit: If successful, this study could enhance pain management strategies for patients undergoing foot or ankle surgery.
How similar studies have gone: Previous studies have shown promising results with similar approaches in regional anesthesia, suggesting potential for success in this trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I-III * adult and scheduled to undergo elective forefoot surgery under regional anaesthesia Exclusion Criteria: * patient refusal * ASA physical status \> III * pregnancy * neuromuscular disorder * prior surgery in the popliteal fossa * coagulopathy * allergy to local anaesthetic drugs * skin infection at the site of needle insertion
Where it's running
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Prince of Wales Hospital
Shatin, New Territories, Hong Kong Recruiting
Study contacts
- Principal investigator: Manoj K Karmakar, MD — Chinese University of Hong Kong
- Study coordinator: Ayla Wong, RN, BN
- Email: aylawong@cuhk.edu.hk
- Phone: +85235056157
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.