Comparing Lidocaine and Levobupivacaine for Sciatic Nerve Block in Foot Surgery
A Prospective Randomized Comparison of the Effects of Lidocaine and Levobupivacaine on Block Dynamics After a Subparaneural Popliteal Sciatic Nerve Block
PHASE4 · Chinese University of Hong Kong · NCT04397484
This study is testing which of two local anesthetics, Lidocaine or Levobupivacaine, works better for numbing the leg during foot surgery.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Chinese University of Hong Kong (other) |
| Locations | 1 site (Shatin, New Territories) |
| Trial ID | NCT04397484 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of two local anesthetics, Lidocaine and Levobupivacaine, in performing ultrasound-guided subparaneural popliteal sciatic nerve blocks for patients undergoing elective forefoot surgery. The study will enroll 40 patients and assess the block dynamics, including onset time and duration of anesthesia. By evaluating the differences in block performance between the two anesthetics, the trial seeks to identify the optimal choice for regional anesthesia in this surgical context.
Who should consider this trial
Good fit: Ideal candidates are adults scheduled for elective forefoot surgery with an ASA physical status of I-III.
Not a fit: Patients with ASA physical status greater than III, pregnancy, or allergies to local anesthetics may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance pain management strategies for patients undergoing foot or ankle surgery.
How similar studies have performed: Previous studies have shown promising results with similar approaches in regional anesthesia, suggesting potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I-III * adult and scheduled to undergo elective forefoot surgery under regional anaesthesia Exclusion Criteria: * patient refusal * ASA physical status \> III * pregnancy * neuromuscular disorder * prior surgery in the popliteal fossa * coagulopathy * allergy to local anaesthetic drugs * skin infection at the site of needle insertion
Where this trial is running
Shatin, New Territories
- Prince of Wales Hospital — Shatin, New Territories, Hong Kong (RECRUITING)
Study contacts
- Principal investigator: Manoj K Karmakar, MD — Chinese University of Hong Kong
- Study coordinator: Ayla Wong, RN, BN
- Email: aylawong@cuhk.edu.hk
- Phone: +85235056157
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Musculoskeletal Diseases or Conditions, RCT, Lidocaine vs levobupivacaine, sciatic nerve block