Comparing left bundle branch pacing to standard right ventricular pacing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of left bundle branch pacing (LBBP) compared to standard right ventricular pacing (RVP) in patients with high-degree atrioventricular block. The study aims to determine if LBBP can reduce cardiovascular death, heart failure events, and changes in left ventricular size over time. Patients will undergo echocardiograms and NTproBNP tests at various intervals to monitor their heart function and health outcomes. The trial focuses on individuals who are expected to require significant ventricular pacing due to their heart condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years
2. Patients with an ejection fraction of \>35%
3. Patients with an indication for ventricular pacing and high-degree atrioventricular block where the degree of anticipated RV pacing is \>90% including:

   1. Third degree AV block
   2. Symptomatic or asymptomatic second-degree AV block
   3. First degree AV block ≥ 280ms with a narrow QRS, or ≥ 240ms with an intraventricular delay (QRS duration ≥120ms)
4. Echocardiogram within the last 3 months, with ability to have DICOM images

Exclusion Criteria:

1. Indication for an implantable cardioverter defibrillator
2. Presence of a mechanical tricuspid valve
3. Any prior attempt at implantation of an ICD, CRT, HBP, or LBBP
4. Lack of capacity to consent
5. Other serious medical condition with life expectancy of \<2 years
6. Pregnancy
7. Patients in whom the conduction system abnormality is expected to be transient or recover over time
8. Patients with permanent atrial fibrillation

Where it's running

• McGill University Health Centre-Research Institute
  Montreal, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Jacqueline Joza, MD MSc
• Email: jacqueline.joza@gmail.com
• Phone: 514-934-1934

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.