Comparing laser treatment and magic mouthwash for pain relief in kids with mouth ulcers
Official title: Effects of Photobiomodulation on Pain After Presentation of Aphthous Ulcers in Pediatric Dental Patients
Run by The University of Texas Health Science Center, Houston · NCT06819033 · Data updated 2026-11-12
This study is testing whether laser treatment works better than Magic Mouthwash to help kids with painful mouth ulcers feel better.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 5 Years to 17 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | March 10, 2025 |
| Main results expected | February 27, 2026 |
| Study ends | February 28, 2026 |
| Registry record updated | March 25, 2025 |
| Trial ID | NCT06819033 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pediatric patients who present with one or more aphthous ulcers and have not previously received PBM treatment for these ulcers.
✕Probably not a fit
Patients with herpes labialis or systemic diseases affecting soft tissue healing may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of laser photobiomodulation (PBM) compared to 'Magic Mouthwash' in alleviating pain associated with aphthous ulcers in pediatric dental patients. It will assess how PBM influences the healing rate of these ulcers and measure changes in pain levels reported by the children undergoing treatment. The study will involve pediatric patients presenting with one or more aphthous ulcers during their dental appointments, with follow-up assessments conducted to monitor outcomes.
Why it matters
Potential benefit: If successful, this study could provide a more effective pain management option for children suffering from aphthous ulcers.
How similar studies have gone: While there is ongoing research in the field of photobiomodulation, this specific comparison of PBM and Magic Mouthwash in pediatric patients is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient/guardian speaks either English or Spanish * Patient presenting with one or more aphthous ulcers in their mouth, identified during a scheduled dental appointment * No previous PBM treatment to the presenting aphthous ulcer(s) * Guardian able to partake in a follow-up phone call in either the English or Spanish language Exclusion Criteria: * Patient presents with aphthous ulcers recently treated with PBM * Patient presents with herpes labialis (cold sores) * Patients presents with systemic disease that affects soft tissue/mucous healing
Where it's running
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The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Brett Chiquet, DDS, PhD — The University of Texas Health Science Center, Houston
- Study coordinator: Brett Chiquet, DDS, PhD
- Email: Brett.T.Chiquet@uth.tmc.edu
- Phone: (713) 500-8220
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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OROSEDAL use in sore throat and minor oral lesions
This is a real-world, non-interventional study checking how well OROSEDAL works and how safe it is in people aged 8 and older who have sore throats or small mouth lesions in routine clinical practice.
-
Saliva levels of E-cadherin, calprotectin, and MMP-9 in people with recurrent mouth ulcers.
This will test whether three saliva proteins (E-cadherin, calprotectin, and MMP-9) are different in adults with minor recurrent aphthous stomatitis compared with healthy adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.