Comparing laser therapy and open surgery for temporal lobe epilepsy
Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy: A Prospective, Randomized, Open Blinded, End-point Trial
NA · Beijing Tiantan Hospital · NCT06720922
This study is testing whether laser therapy works better than traditional surgery for people with drug-resistant temporal lobe epilepsy to see how well each option controls seizures.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Sex | All |
| Sponsor | Beijing Tiantan Hospital (other) |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06720922 on ClinicalTrials.gov |
What this trial studies
This study compares the clinical outcomes of magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) with traditional open surgery for patients suffering from drug-resistant temporal lobe epilepsy (TLE). It aims to evaluate how these two interventions affect seizure control and overall prognosis. Additionally, the study will investigate various factors that may influence the success of seizure outcomes in these patients.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with drug-resistant temporal lobe epilepsy who have been approved for surgical intervention.
Not a fit: Patients with significant medical comorbidities or a history of brain surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a less invasive treatment option for patients with temporal lobe epilepsy, potentially improving their quality of life.
How similar studies have performed: Other studies have shown promising results with MRgLITT in treating epilepsy, suggesting that this approach may be effective, though it is still considered a novel intervention compared to traditional methods.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-65 years. * Drug-resistant mesial temporal lobe epilepsy. * Seizure frequency ≥ 1 time /month. * Participants approved. Exclusion Criteria: * History of brain surgery. * Intracranial space occupying lesions. * Individuals with significant medical comorbidities or conditions that pose an excessive risk for surgery, such as severe cardiovascular disease, respiratory disorders, or uncontrolled systemic infections.
Where this trial is running
Beijing, Beijing Municipality
- Beijing Tiantan Hospital — Beijing, Beijing Municipality, China (RECRUITING)
Study contacts
- Study coordinator: Kai Zhang, Dr.
- Email: zhangkai62035@sina.com
- Phone: 86 01059975051
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Temporal Lobe Epilepsy, Magnetic Resonance-guided Laser Interstitial Thermal Therapy, Open Surgery