Comparing Lactated Ringers and Normal Saline for Acute Pancreatitis Treatment
Lactated Ringers vs Normal Saline in Patients With Acute Pancreatitis: A Bias-Adjusted Meta-analysis
This study is testing whether Lactated Ringers or Normal Saline works better to treat people with acute pancreatitis and reduce the risk of serious complications.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Sex | All |
| Sponsor | Qatar University Academic / other |
| Locations | 1 site (Doha) |
| Trial ID | NCT05638555 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare the effectiveness of Lactated Ringers (LR) versus Normal Saline (NS) in treating patients with acute pancreatitis. It will address methodological issues found in existing meta-analyses by conducting a comprehensive database search for relevant studies and performing a bias-adjusted synthesis of the data. The primary outcome of interest is the incidence of Systemic Inflammatory Response Syndrome (SIRS) within 24 hours of treatment. The study will evaluate the quality of existing evidence and provide new insights into optimal fluid rehydration therapy for this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are adults diagnosed with acute pancreatitis who are part of randomized controlled trials or observational studies comparing NS and LR.
Not a fit: Patients with acute pancreatitis who are part of pediatric populations or those involved in animal studies will not benefit from this research.
Why it matters
Potential benefit: If successful, this study could help identify the most effective fluid therapy for patients with acute pancreatitis, potentially improving patient outcomes.
How similar studies have performed: Previous studies have shown conflicting results regarding fluid therapy in acute pancreatitis, making this approach both relevant and necessary to clarify existing uncertainties.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * RCTs and observational studies that compared NS vs LR in AP patients. * Studies reviewed must report data as effect estimates or provide raw data sufficient to calculate effect estimates. Exclusion Criteria: * Studies involving animal studies, pediatric patient populations, and cell lines will be excluded. All studies will be reviewed in full form by each author to determine eligibility. In case of disagreement, determination of inclusion will be reached via consensus.
Where this trial is running
Doha
- Suhail Doi — Doha, Qatar (Recruiting)
Study contacts
- Principal investigator: Suhail Doi — Qatar University
- Study coordinator: Suhail Doi
- Email: sdoi@qu.edu.qa
- Phone: 0097444037854
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.