Comparing ketamine and magnesium sulfate for sore throat relief after nasal surgery
The Effect of Oropharyngeal Pack Soaked With Ketamine or Magnesium Sulphate on Post Operative Sore Throat After Nasal Surgeries: Randomized Controlled Double Blind Study
This study is testing whether using ketamine or magnesium sulfate in throat packs can help adults feel less sore after having nasal surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Beni-Suef University Academic / other |
| Locations | 1 site (Banī Suwayf) |
| Trial ID | NCT05714540 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of oropharyngeal packs soaked in either ketamine or magnesium sulfate in reducing the incidence and severity of postoperative sore throat (POST) following elective nasal surgeries performed under general anesthesia. The research will involve 90 adult patients classified as ASA physical status I and II, who will undergo various nasal procedures. The primary outcome will focus on the reduction of POST, while secondary outcomes will assess postoperative nausea and vomiting. The study will compare the effects of these two interventions against a saline control to determine the most effective approach for alleviating these common postoperative complications.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 60 with ASA physical status I or II scheduled for elective nasal surgery requiring general anesthesia.
Not a fit: Patients with a history of recent respiratory infections, known allergies to the study drugs, or those requiring difficult intubation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce the incidence of postoperative sore throat and nausea, improving recovery experiences for patients undergoing nasal surgery.
How similar studies have performed: While the use of oropharyngeal packs in nasal surgeries is common, the specific comparison of ketamine and magnesium sulfate for this purpose is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The study will include 90 adult patients of American Society of Anesthesiologists (ASA) physical status I and II, in the age group of 18 to 60 years of age, of either sex, who will be scheduled for elective nasal surgery (e.g. unilateral or bilateral functional endoscopic sinus surgery, sub mucousal resection, septorhinoplasty , polypectomy) under general anesthesia with endotracheal intubation, having a Mallampatti Grades of I and II and those who are willing to give informed consent. Exclusion Criteria: * History of recent respiratory tract infection or sore throat , anticipated difficult airway, known allergy to study drug, and preoperative use of analgesics such as non-steroidal anti-inflammatory drugs or opioids, Patients who required more than one attempt for tracheal intubation, or who will need tracheal intubation of \<60 minutes or\>300 minutes will be eliminated from the study.
Where this trial is running
Banī Suwayf
- Faculty of medicine beni Suef university — Banī Suwayf, Egypt (Recruiting)
Study contacts
- Study coordinator: Jehan Mohamed Mohamed, MD
- Email: jehanmohamed1510@gmail.com
- Phone: 00201110269572
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.