Comparing Ketalar and Dexmedetomidine for Pain Sensitivity After Remifentanil
Comparison of the Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Induced Following Treatment With Remifentanil in Patients Undergoing a Laparoscopic Cholecystectomy
This study is testing whether Ketalar or Dexmedetomidine can help reduce pain sensitivity after surgery in patients who have received Remifentanil.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Assaf-Harofeh Medical Center Government |
| Locations | 1 site (Be’er Ya‘aqov) |
| Trial ID | NCT06473896 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of Ketalar and Dexmedetomidine in preventing increased sensitivity to pain, known as hyperalgesia, following the use of Remifentanil during laparoscopic cholecystectomy. Remifentanil is a potent opioid with a short half-life, but it can lead to heightened pain sensitivity after its administration. By comparing these two complementary treatments, the study seeks to identify which option better alleviates pain sensitivity in patients undergoing this surgical procedure. The study will involve patients scheduled for laparoscopic cholecystectomy under general anesthesia.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for laparoscopic cholecystectomy who will receive general anesthesia.
Not a fit: Patients with chronic pain, those requiring urgent surgery, or individuals with specific cardiac or renal issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing surgery, reducing reliance on opioids.
How similar studies have performed: Other studies have explored the use of alternative analgesics in opioid-sparing strategies, showing promising results, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Patients who are about to undergo alaparoscopic cholecystectomy under general anesthesia Exclusion Criteria: * Patients with sensitivity to the anesthetic * Patients with chronic pain who are in regular treatment * Urgent surgery * Patients with ischemic heart disease * Patients with known bradycardia * Patients with a pacemaker * Prolonged use of opiates * Kidney/liver function problems
Where this trial is running
Be’er Ya‘aqov
- Shamir (Asaf Harofe) Medical Center — Be’er Ya‘aqov, Israel (Recruiting)
Study contacts
- Study coordinator: Sara Bar Yehuda, PhD
- Email: sarabar1@shamir.gov.il
- Phone: 972528981004
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.