Comparing intubation conditions using rocuronium and succinylcholine

Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine : A Prospective Non-inferiority Randomized and Blind Trial

This study tests whether using rocuronium or succinylcholine makes it easier and safer to put a breathing tube in patients during surgery.

Quick facts

• Phase: PHASE4
• Study type: Interventional
• Enrollment: 152 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: The University of Texas Health Science Center, Houston (other)
• Locations: 1 site (Houston, Texas)
• Trial ID: NCT06029049 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate and compare the conditions for tracheal intubation achieved with modified time principal induction using 0.6 mg/kg rocuronium versus 1 mg/kg succinylcholine. The investigators will assess factors such as ease of laryngoscopy, vocal cord view, vocal cord opening, and patient movement during intubation. The goal is to determine the efficiency and success rates of intubation with these two agents, as well as the incidence of patient awareness during induction and postoperative recall of paralysis.

Who should consider this trial

Good fit: Ideal candidates include individuals with a BMI greater than 30 kg/m2 or those classified as Mallampati class III or IV who require general anesthesia and endotracheal intubation.

Not a fit: Patients with acute or chronic respiratory disorders, severe comorbidities, or those requiring awake intubation may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve intubation practices and patient safety during anesthesia.

How similar studies have performed: Previous studies have shown varying success with different induction agents, but this specific comparison is novel.

Eligibility criteria

Inclusion Criteria:

* BMI \> 30kg/m2 or Mallampati class III or IV.
* Requiring general anesthesia and endotracheal intubation

Exclusion Criteria:

* Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease(COPD) and asthma.
* The American Society of Anesthesiologists (ASA) physical status classification \> III.
* Patients requiring awake intubation.
* Pregnant women.
* Untreated ischemic heart disease.
* Patients requiring an induction dose of propofol \< 1 mg/kg.
* Allergy to propofol, rocuronium, succinylcholine, or sugammadex.
* Patients with renal failure and unknown potassium (K+) level, or patients with K+ level \> 5.0
* Personal history of malignant hyperthermia (MH), or family history of MH
* Patients with suspected or diagnosed neuromuscular disease, patients with burn injuries

Where this trial is running

Houston, Texas

• The University of Texas Health Science Center at Houston — Houston, Texas, United States (RECRUITING)

Study contacts

• Principal investigator: Lauren M Nakazawa, MD,MBA — The University of Texas Health Science Center, Houston
• Study coordinator: Lauren M Nakazawa, MD,MBA

Conditions: Anesthesia