Comparing intubation conditions using rocuronium and succinylcholine
Official title: Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine : A Prospective Non-inferiority Randomized and Blind Trial
Run by The University of Texas Health Science Center, Houston · NCT06029049 · Data updated 2026-11-12
This study tests whether using rocuronium or succinylcholine makes it easier and safer to put a breathing tube in patients during surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 152 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | September 13, 2023 |
| Main results expected | June 1, 2025 |
| Study ends | July 1, 2025 |
| Registry record updated | December 10, 2024 |
| Trial ID | NCT06029049 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a BMI greater than 30 kg/m2 or those classified as Mallampati class III or IV who require general anesthesia and endotracheal intubation.
✕Probably not a fit
Patients with acute or chronic respiratory disorders, severe comorbidities, or those requiring awake intubation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate and compare the conditions for tracheal intubation achieved with modified time principal induction using 0.6 mg/kg rocuronium versus 1 mg/kg succinylcholine. The investigators will assess factors such as ease of laryngoscopy, vocal cord view, vocal cord opening, and patient movement during intubation. The goal is to determine the efficiency and success rates of intubation with these two agents, as well as the incidence of patient awareness during induction and postoperative recall of paralysis.
Why it matters
Potential benefit: If successful, this study could improve intubation practices and patient safety during anesthesia.
How similar studies have gone: Previous studies have shown varying success with different induction agents, but this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI \> 30kg/m2 or Mallampati class III or IV. * Requiring general anesthesia and endotracheal intubation Exclusion Criteria: * Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease(COPD) and asthma. * The American Society of Anesthesiologists (ASA) physical status classification \> III. * Patients requiring awake intubation. * Pregnant women. * Untreated ischemic heart disease. * Patients requiring an induction dose of propofol \< 1 mg/kg. * Allergy to propofol, rocuronium, succinylcholine, or sugammadex. * Patients with renal failure and unknown potassium (K+) level, or patients with K+ level \> 5.0 * Personal history of malignant hyperthermia (MH), or family history of MH * Patients with suspected or diagnosed neuromuscular disease, patients with burn injuries
Where it's running
-
The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Lauren M Nakazawa, MD,MBA — The University of Texas Health Science Center, Houston
- Study coordinator: Lauren M Nakazawa, MD,MBA
- Email: Lauren.M.Nakazawa@uth.tmc.edu
- Phone: 713-500-6775
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.