Comparing intensive and standard blood sugar control in hospitalized patients with diabetes
Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients
This study tests whether tighter blood sugar control with insulin helps hospitalized patients with diabetes feel better compared to standard treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 600 (estimated) |
| Ages | 18 Years to 120 Years |
| Sex | All |
| Sponsor | Rabin Medical Center Academic / other |
| Locations | 2 sites (Haifa and 1 other locations) |
| Trial ID | NCT03510078 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of intensive versus conventional hyperglycemic control in hospitalized non-critically ill patients with diabetes. It aims to determine the optimal glucose target range for these patients, as current practices lack clear evidence-based guidelines. The study will involve a prospective randomized controlled design, where participants will receive either intensive or standard insulin treatment within 24 hours of hospitalization. The goal is to assess the impact of these different approaches on patient outcomes during their hospital stay.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old with a history of type 2 diabetes and a minimum of three days of hospitalization.
Not a fit: Patients experiencing diabetic ketoacidosis, those requiring intensive care, or individuals with current substance abuse or mental health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of blood sugar levels in hospitalized patients, potentially reducing complications and improving overall health outcomes.
How similar studies have performed: Previous studies have shown conflicting results regarding glycemic control in hospitalized patients, indicating that this approach is still under investigation and not yet fully established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age older than 18 years old. * History of type 2 diabetes mellitus for at least three months or a blood glucose level of 200 mg per deciliter or higher in two different consecutive measurements. * A minimum of three days of hospitalization. Exclusion Criteria: * Diabetic ketoacidosis or hyperosmolar non-ketotic state at any stage of hospitalization. * Patients expected to require intensive care unit admission or immediate surgical intervention. * History of current drug or alcohol abuse. * History of current mental illness. * Child-bearing potential or a positive urine pregnancy test.
Where this trial is running
Haifa and 1 other locations
- Rambam Medical Center — Haifa, Israel (Recruiting)
- Rabin Medical Center — Petah Tikva, Israel (Recruiting)
Study contacts
- Study coordinator: Alon Grossman, Prof
- Email: along@clalit.org.il
- Phone: +972-504065545
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.