Comparing individuals with gender dysphoria to a control group

Comparative Study of Gender Dysphoria Phenomenology and Neurophysiology: Clinical and Experimental Exploration of Gender Identity Disorder

Observational Centre Hospitalier Henri Laborit · NCT04935164

This study looks at the experiences and brain connections of people with gender dysphoria compared to others to see how their feelings about their gender affect their mood and self-awareness.

Quick facts

Study typeObservational
Enrollment120 (estimated)
Ages18 Years to 60 Years
SexAll
SponsorCentre Hospitalier Henri Laborit Academic / other
Locations1 site (Poitiers)
Trial IDNCT04935164 on ClinicalTrials.gov

What this trial studies

This observational study aims to explore the experiences and brain connectivity of individuals diagnosed with gender dysphoria compared to a control group. It focuses on understanding the internal conflict between biological sex and gender identity, and how this may affect mood and self-awareness. Participants will undergo psychiatric evaluations to assess their mental health status and the impact of their condition. The study seeks to gather data that could enhance the understanding of gender dysphoria and its neurological underpinnings.

Who should consider this trial

Good fit: Ideal candidates for this study are adults diagnosed with gender dysphoria who are not currently undergoing psychotropic treatment, hormone therapy, or sexual reassignment surgery.

Not a fit: Patients with concurrent depression or addiction issues may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment approaches and better quality of life for individuals with gender dysphoria.

How similar studies have performed: While there have been studies on gender dysphoria, this specific approach focusing on brain connectivity and self-awareness is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with gender dysphoria
* Without psychotropic
* Without hormono-therapy
* Without sexual surgery assignation

Exclusion Criteria:

* Any depression
* Any addiction

Where this trial is running

Poitiers

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Gender Dysphoria, Adult
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.