Comparing immune responses from COVID-19 infection and vaccination
Comparison of the Immune Response to Natural COVID-19 Infection and Vaccination
This study is trying to see how the immune responses from getting COVID-19 and from vaccination compare in healthcare workers and people who have had the virus before.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2500 (estimated) |
| Ages | 20 Years to 100 Years |
| Sex | All |
| Sponsor | University of Bergen Academic / other |
| Locations | 1 site (Bergen) |
| Trial ID | NCT04706390 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare the immune responses generated by natural SARS-CoV-2 infection and COVID-19 vaccination. It will recruit subjects prioritized for vaccination, including healthcare workers and patients previously infected with the virus. The study will collect demographic and clinical data, along with repeated blood samples, to evaluate the kinetics, duration, and breadth of antibody responses, as well as B and T cellular responses. Additionally, it will assess short and long-term complications associated with both natural infection and vaccination.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals prioritized by the national vaccination program, including healthcare workers and previously infected patients.
Not a fit: Patients who are children or those unable or unwilling to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the most effective immune responses to COVID-19, guiding vaccination strategies.
How similar studies have performed: Other studies have shown success in comparing immune responses to COVID-19 infection and vaccination, making this approach both relevant and necessary.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * subjects prioritized by national vaccination program Exclusion Criteria: * Children * unable or unwilling to provide informed consent
Where this trial is running
Bergen
- University of Bergen — Bergen, Norway (Recruiting)
Study contacts
- Principal investigator: Rebecca J Cox, PhD — University of Bergen
- Study coordinator: Rebecca J Cox, PhD
- Email: rebecca.cox@uib.no
- Phone: +4745242974
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.