Clinical trial Recruiting at 1 site Observational Ages 20 to 100

Comparing immune responses from COVID-19 infection and vaccination

Official title: Comparison of the Immune Response to Natural COVID-19 Infection and Vaccination

Run by University of Bergen · NCT04706390 · Data updated 2026-11-12

This study is trying to see how the immune responses from getting COVID-19 and from vaccination compare in healthcare workers and people who have had the virus before.

Quick facts

Study typeObservational
Ages20 Years to 100 Years
SexAll
Enrollment2500 (estimated)
SponsorUniversity of Bergen
Academic / other
Locations1 site (Bergen)
StatusRecruiting
StartedJanuary 12, 2021
Main results expectedDecember 12, 2024
Study endsDecember 12, 2030
Registry record updatedApril 19, 2024
Trial IDNCT04706390 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals prioritized by the national vaccination program, including healthcare workers and previously infected patients.

Probably not a fit

Patients who are children or those unable or unwilling to provide informed consent will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to compare the immune responses generated by natural SARS-CoV-2 infection and COVID-19 vaccination. It will recruit subjects prioritized for vaccination, including healthcare workers and patients previously infected with the virus. The study will collect demographic and clinical data, along with repeated blood samples, to evaluate the kinetics, duration, and breadth of antibody responses, as well as B and T cellular responses. Additionally, it will assess short and long-term complications associated with both natural infection and vaccination.

Why it matters

Potential benefit: If successful, this study could provide insights into the most effective immune responses to COVID-19, guiding vaccination strategies.

How similar studies have gone: Other studies have shown success in comparing immune responses to COVID-19 infection and vaccination, making this approach both relevant and necessary.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* subjects prioritized by national vaccination program

Exclusion Criteria:

* Children
* unable or unwilling to provide informed consent

Where it's running

  • University of Bergen
    Bergen, Norway
    Recruiting

Study contacts

  • Principal investigator: Rebecca J Cox, PhD — University of Bergen
  • Study coordinator: Rebecca J Cox, PhD
  • Email: rebecca.cox@uib.no
  • Phone: +4745242974

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.