Comparing immune responses from COVID-19 infection and vaccination
Official title: Comparison of the Immune Response to Natural COVID-19 Infection and Vaccination
Run by University of Bergen · NCT04706390 · Data updated 2026-11-12
This study is trying to see how the immune responses from getting COVID-19 and from vaccination compare in healthcare workers and people who have had the virus before.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 100 Years |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | University of Bergen Academic / other |
| Locations | 1 site (Bergen) |
| Status | Recruiting |
| Started | January 12, 2021 |
| Main results expected | December 12, 2024 |
| Study ends | December 12, 2030 |
| Registry record updated | April 19, 2024 |
| Trial ID | NCT04706390 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals prioritized by the national vaccination program, including healthcare workers and previously infected patients.
✕Probably not a fit
Patients who are children or those unable or unwilling to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to compare the immune responses generated by natural SARS-CoV-2 infection and COVID-19 vaccination. It will recruit subjects prioritized for vaccination, including healthcare workers and patients previously infected with the virus. The study will collect demographic and clinical data, along with repeated blood samples, to evaluate the kinetics, duration, and breadth of antibody responses, as well as B and T cellular responses. Additionally, it will assess short and long-term complications associated with both natural infection and vaccination.
Why it matters
Potential benefit: If successful, this study could provide insights into the most effective immune responses to COVID-19, guiding vaccination strategies.
How similar studies have gone: Other studies have shown success in comparing immune responses to COVID-19 infection and vaccination, making this approach both relevant and necessary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * subjects prioritized by national vaccination program Exclusion Criteria: * Children * unable or unwilling to provide informed consent
Where it's running
-
University of Bergen
Bergen, Norway Recruiting
Study contacts
- Principal investigator: Rebecca J Cox, PhD — University of Bergen
- Study coordinator: Rebecca J Cox, PhD
- Email: rebecca.cox@uib.no
- Phone: +4745242974
Similar studies
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This study looks at how COVID-19 affects people in different ways, including those with long-term symptoms, to learn more about the disease and its progression.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.