Comparing immediate vs. delayed placement of dental crowns on implants after tooth extraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves participants who need a lower first molar extracted and replaced with a dental implant. After the extraction, the implant will be placed 12-16 weeks later, with half of the participants receiving an artificial tooth immediately and the other half receiving it four weeks later. The study aims to compare the success rates and tissue health between these two loading protocols using modern implant techniques. The goal is to provide evidence for the effectiveness of immediate loading in dental implant procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 20 years
* Willingness to sign informed consent and to participate in the study
* Plaque index according to Silness and Loe of \< 35% \[26\]
* Presence of a mandibular first molar that has to be extracted
* Sufficient vertical interocclusal space for the placement of an implant crown (7 mm)
* Presence of an opposing natural or artificial tooth
* Ridge height sufficient for the placement of a ≥ 10 mm-long implant
* Sufficient ridge width for the placement of a 4.1mm diameter implant

Exclusion Criteria:

* Any physical or mental disorder that would interfere with the ability to perform adequate oral hygiene or the capability of providing written informed consent and compliance to the protocol
* Any disorder that would interfere with wound healing or represent a contraindication for implant surgery such as, but not limited to, uncontrolled diabetes or conditions resulting in or requiring immunosuppression, radiation, chemotherapy, frequent use of antibiotics or antiresorptive medication such as bisphosphonates
* Pregnancy or lactation
* Intention to become pregnant between inclusion and implant loading
* Heavy smoking habit with ≥ 10 cig/d
* Severe bruxism or clenching habits, present oro-facial pain
* Insufficient ridge width/height for the study implant
* Defect of any alveolar wall (secondary exclusion criterion at tooth extraction)
* ISQ \< 70 (secondary exclusion criterion for Group A at implant placement, for Group B at loading visit)

Where it's running

• Klinik für Oralchirurgie und Stomatologie
  Bern, Canton of Bern, Switzerland Recruiting
• Klinik für rekonstruktive Zahnmedizin und Gerodontologie
  Bern, Canton of Bern, Switzerland Recruiting

Study contacts

• Principal investigator: Simone FM Janner, PD Dr. — University of Bern
• Study coordinator: Simone FM Janner, PD Dr.
• Email: ueberweiser.chir@zmk.unibe.ch
• Phone: +41316322566

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• International effort to set liver CEUS image-quality standards and a rating tool

  A group of experts is testing a standardized set of quality criteria and a rating tool to judge liver CEUS images.

  Recruiting University of Bern · Bern, Canton of Bern · NCT07656181

• Hyaluronic acid to improve healing after endodontic microsurgery

  This trial will test whether adding cross-linked hyaluronic acid during endodontic microsurgery helps adults with apical periodontitis of first molars heal faster and have less pain.

  Recruiting University of Bern · Moscow · NCT07501585

• Volume-stable collagen matrix to cover gum recession on teeth

  This test checks whether a new volume-stable collagen matrix can replace a connective tissue graft from the palate to cover buccal gum recessions in adults.

  Recruiting University of Bern · Bern · NCT07437417

• Blood markers and vascular function testing for people with persistent symptoms after COVID-19 vaccination

  This project will test blood tests and a finger-based vascular scan (EndoPAT) in adults who developed long-lasting symptoms after a COVID-19 vaccine to see how symptoms and biological signs change over time.

  Recruiting University of Bern · Bern · NCT07400848

• MASLD development in breast and colorectal cancer survivors

  This project will see how common MASLD and liver fibrosis are in adults who survived breast or colorectal cancer 5–10 years after diagnosis.

  Recruiting University of Bern · Bern · NCT07280143

• Weak electrical stimulation of the left dorsolateral prefrontal cortex and its effects on information processing

  This project will test whether weak electrical brain stimulation of the left dlPFC changes brain activity and task performance in healthy younger and older adults.

  Recruiting University of Bern · Bern · NCT07168031

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.