Comparing immediate and delayed frozen embryo transfer for live birth rates
A Randomized Trial Comparing the Live Birth Rate of Immediate Versus Delayed Frozen Embryo Transfer (FET) Replacing a Single Blastocyst in the First FET of the First Stimulated IVF Cycle Following a Freeze-all Strategy
This study is testing whether women undergoing their first IVF cycle have better chances of having a baby with immediate frozen embryo transfer compared to waiting for a delayed transfer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 828 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | Female |
| Sponsor | ShangHai Ji Ai Genetics & IVF Institute Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT04371783 on ClinicalTrials.gov |
What this trial studies
This trial aims to compare the live birth rates of immediate versus delayed frozen embryo transfer (FET) following a freeze-all strategy in women undergoing their first IVF cycle. Participants will be randomly assigned to receive either an immediate or delayed FET after the freezing of a single blastocyst. The study will also assess anxiety levels and hormone levels on Day 3 of the menstrual cycle to evaluate any potential impacts on outcomes. The hypothesis is that immediate FET will yield a higher live birth rate compared to delayed FET.
Who should consider this trial
Good fit: Ideal candidates are women aged 20-40 who are undergoing their first FET of the first IVF cycle following a freeze-all strategy.
Not a fit: Patients with severe ovarian hyperstimulation syndrome, those requiring preimplantation genetic testing, or using donor oocytes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help optimize FET timing, potentially increasing live birth rates for women undergoing IVF.
How similar studies have performed: Other studies have explored FET timing, but this specific comparison of immediate versus delayed FET following a freeze-all strategy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Women aged 20-40 years at the time of IVF/ICSI 2. Women undergoing their first FET of the first IVF cycle following a freeze-all strategy 3. Undergoing IVF with GnRH antagonist 4. At least one frozen blastocyst Exclusion Criteria: 1. Severe ovarian hyperstimulation syndrome during the first IVF/ICSI cycle 2. Preimplantation genetic testing 3. Use of donor oocytes 4. Presence of untreated hydrosalpinx or endometrial polyp on scanning during ovarian stimulation
Where this trial is running
Shanghai, Shanghai
- Shanghai JiAi Genetics & IVF Institute — Shanghai, Shanghai, China (Recruiting)
Study contacts
- Study coordinator: He Li, Md
- Email: lihe198900@163.com
- Phone: +8602163459977
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.