Comparing imaging techniques for heart artery treatment in heart attack patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the clinical outcomes of two different imaging techniques—optical coherence tomography (OCT) and traditional angiography—during percutaneous coronary intervention (PCI) in patients experiencing acute myocardial infarction (AMI). The research will involve patients who are undergoing primary PCI within 12 hours of symptom onset, assessing how each imaging method influences the effectiveness of the procedure. By utilizing OCT, the study seeks to provide more detailed information on coronary artery lesions and optimize stent placement, potentially leading to better patient outcomes. The findings could help establish a more effective standard of care for AMI patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subject must be at least 19 years of age
* Acute ST-segment elevation myocardial infarction (STEMI)

  \*STEMI: ST-segment elevation ≥0.1 mV in ≥2 contiguous leads or documented newly developed left bundle-branch block1
* Primary percutaneous coronary intervention (PCI) in \< 12 h after the onset of symptoms for STEMI patients
* Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving invasive physiologic evaluation and PCI and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure.

Exclusion Criteria:

* Target lesions not amenable for PCI by operators' decision
* Ostial lesions located in left main vessel or right coronary artery (left main body or distal bifurcation lesions can be enrolled by operator's discretion)
* Creatinine clearance ≤30 ml/min/1.73 m2 and not on dialysis (chronic dialysis dependent patients are eligible for enrolment regardless of creatinine clearance)
* Cardiogenic shock (Killip class IV) at presentation
* Intolerance to Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Heparin, or Everolimus
* Known true anaphylaxis to contrast medium (not allergic reaction but anaphylactic shock)
* Pregnancy or breast feeding
* Non-cardiac co-morbid conditions are present with life expectancy \<2 year or that may result in protocol non-compliance (per site investigator's medical judgment)
* Unwillingness or inability to comply with the procedures described in this protocol

Where it's running

• Kyungpook National University Hospital
  Daegu, Daegu, South Korea Recruiting
• Yeungnam University Medical Center
  Daegu, Daegu, South Korea Recruiting
• Daegu Catholic University Medical Center
  Daegu, Daegu, South Korea Recruiting
• Chonnam National University
  Gwangju, Gwangju, South Korea Recruiting
• Wonkwang University Hospital
  Iksan, Iksan, South Korea Recruiting
• International St. Mary's Hospital
  Incheon, Incheon, South Korea Recruiting

Study contacts

• Principal investigator: Young Joon Hong, MD, PhD — Chonnam National University
• Study coordinator: Seung Hun Lee, MD, PhD
• Email: lsh8602@naver.com
• Phone: 82-2-220-6246

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.