Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Comparing IFOC and LIFT surgery for high anal fistula.

Official title: Early Outcomes of Intra-anal Fistulotomy With Fistula Opening Closure (IFOC) Compared With Ligation of the Intersphincteric Fistula Tract (LIFT) in High Anal Fistula: A Pilot Randomized Controlled Trial

Run by Cairo University · NCT07520500 · Data updated 2026-11-12

This will test whether IFOC or LIFT surgery leads to better healing and continence for people with high anal fistula.

More Anal Fistula trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment66 (estimated)
SponsorCairo University
Academic / other
Drugs / interventionsradiation
Locations1 site (Cairo, Al-Manial, Cairo, Egypt)
StatusRecruiting
StartedApril 19, 2026
Main results expectedApril 1, 2027
Study endsApril 1, 2027
Registry record updatedMay 22, 2026
Trial IDNCT07520500 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults of any gender with a high anal fistula (involving more than one-third of the sphincter complex) who do not have inflammatory bowel disease, colorectal cancer, prior fecal incontinence, or fistulas caused by trauma or radiation.

Probably not a fit

Patients with IBD, fistulas from cancer, pre-existing fecal incontinence, low anal fistulas, or those unable to attend follow-up are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults presenting with high anal fistula at Kasr Al-Ainy Hospitals will be screened and have preoperative MRI fistulogram and continence scoring. Eligible participants will be randomly assigned 1:1 to receive either the LIFT procedure or the intra-anal fistulotomy with fistula opening closure (IFOC) using standard surgical techniques. Postoperative care will follow the same protocol for both groups with clinical follow-up to document healing, discharge, and continence using the Jorge-Wexner score. Patients with inflammatory bowel disease, colorectal malignancy, pre-existing fecal incontinence, traumatic or radiation-related fistula, or low fistulas are excluded.

Why it matters

Potential benefit: If successful, the comparison could identify the approach that best heals fistulas while preserving bowel continence.

How similar studies have gone: Previous studies of LIFT have generally shown good continence preservation with variable healing rates, while intra-anal closure approaches have produced mixed results, so comparative data are available but not definitive.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with high anal fistula from both gender

Exclusion Criteria:

* Patient with preoperative fecal incontinence
* Fistula secondary to colorectal malignancy
* Patients with inflammatory bowel disease
* Fistula secondary to trauma or radiation
* Low anal fistula

Where it's running

  • Faculty of medicine, Cairo University
    Cairo, Al-Manial, Cairo, Egypt, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.