Comparing hydration from two electrolyte stick drinks versus plain water
Comparison of the Beverage Hydration Index of Different Solutions
This will test whether two electrolyte stick drinks—one with amino acids and one with carbohydrates—help adults stay hydrated better than plain water.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Memphis Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Memphis, Tennessee) |
| Trial ID | NCT07507344 on ClinicalTrials.gov |
What this trial studies
Adults with BMI 18.5–35 who are not highly active will come to the University of Memphis center to drink one liter of each test beverage on separate visits while investigators measure urine output, body water, and blood glucose. Hydration will be quantified by fluid balance and the Beverage Hydration Index, comparing Hydramin (electrolytes plus amino acids), a carbohydrate-electrolyte version, and plain Smart Water. The protocol follows methods used in prior Beverage Hydration Index work at the Center, with added blood glucose and body water measurements. Results will show relative urine production and short-term fluid retention after each drink.
Who should consider this trial
Good fit: Adults aged 18 years or older with BMI 18.5–35 who do no more than about 5 hours per week of aerobic exercise and who do not have medical conditions or medications that affect fluid or electrolyte balance.
Not a fit: People with diabetes, kidney, heart, liver, or other major conditions, or those taking medications that alter fluid retention or electrolytes, are unlikely to benefit or be eligible for this protocol.
Why it matters
Potential benefit: If successful, the findings could identify a convenient drink formulation that helps people maintain fluid balance better than plain water.
How similar studies have performed: Previous Beverage Hydration Index research has shown some drinks retain fluid better than water, carbohydrate-electrolyte solutions have demonstrated benefit in past work, and amino-acid–based mixes are less well studied.
Eligibility criteria
Show full inclusion / exclusion criteria
* Be age 18 years or older * male or female * have a body mass index (BMI)between 18.5-35 kg/m2 (not morbidly obese) * Be engaged in moderate physical activity, defined as ≤5 hours/week of aerobic exercise * Not have a history or presence of a clinically relevant (that required or requires treatment) cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder (reviewed by Nurse practitioner) * Not have other conditions that are likely to alter fluid balance or be negatively affected by changing electrolyte levels/hydration status (as determined by Nurse practitioner) * Not be consuming any medication which may alter fluid retention/electrolyte levels such as Selective Serotonin Reuptake Inhibitors, sodium-glucose co-transporter 2 (SGLT2) inhibitor (for type 2 diabetes), laxatives, diuretics, Apremilast, chemotherapy, or lithium. (Medications will be reviewed by Nurse practitioner) * Not consume nutritional supplements, performance enhancing drugs, and/or non-steroidal anti-inflammatory drugs within 7 days of study visits excluding screening. * Follow the lifestyle and dietary restrictions before study visits (excluding screening/consenting visit) including before each visit avoiding strenuous activity for 24 hours prior, refrain from caffeine for 12 hours and alcohol for 24 hours, consume the standardized diet and maintain similar activity levels for 24 hours prior, consume 2.5 liters for men or 2.0 liters for women day prior, and fast (water only) of at least 10 hours prior. * Not have a sensitivity or be allergic to any components of the study interventions (water, calcium chloride, magnesium chloride, potassium bicarbonate, magnesium, sodium, chloride, potassium, vitamin C, dextrose, AminoAbsorb (L-alanine, L-glutamine, glycine). * Not be a tobacco user * Not be following a specialized dietary pattern that may alter findings (e.g., low carbohydrate/ketogenic diet, carnivore diet, intermittent fasting etc.) * Arrive to lab for visits euhydrated (USG 1.005-1.020) * Have the ability and willingness to fast (consume water/treatments only) for 15 hours (10 hours prior to lab visits not including screening) * Not be enrolled in another clinical study within 30 days of the first study visit * Be without active infection or illness of any kind * Not be pregnant or breastfeeding * Not have surgery in the previous 4 months
Where this trial is running
Memphis, Tennessee
- Center for Nutraceutical and Dietary Supplement Research — Memphis, Tennessee, United States (Recruiting)
Study contacts
- Study coordinator: Jacquelyn Pence, PhD
- Email: jpence1@memphis.edu
- Phone: 901-678-1547
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.