Comparing Hyaluronic Acid Injection to Normal Saline for Knee Osteoarthritis
The Efficacy of Hyaluronic Acid Injection as an Adjunctive Treatment After Intraarticular Low-dose Glucocorticoid Injection for Symptomatic Knee Osteoarthritis: A Multicenter Randomized, Controlled, Double-blinded Study
This study is testing if Hyaluronic acid injections can help people with knee osteoarthritis feel less pain and move better compared to regular saline injections.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 176 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Phramongkutklao College of Medicine and Hospital Academic / other |
| Locations | 1 site (Bangkok) |
| Trial ID | NCT06279507 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of Hyaluronic acid injections in alleviating symptoms of knee osteoarthritis, including pain, stiffness, and joint function. Participants diagnosed with knee osteoarthritis will receive either Hyaluronic acid or normal saline injections following a glucocorticoid injection. The study will assess improvements in knee performance and health-related quality of life over a follow-up period of 12 and 24 weeks. The primary goal is to determine if Hyaluronic acid provides superior benefits compared to a placebo.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with knee osteoarthritis who experience moderate to severe knee pain.
Not a fit: Patients with cognitive impairments, serious comorbidities, or those currently pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly improve pain management and quality of life for patients with knee osteoarthritis.
How similar studies have performed: Previous studies have shown promising results for Hyaluronic acid injections in treating knee osteoarthritis, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All participants who had been diagnosed as knee osteoarthritis according to ACR criteria with symptom of knee pain * Pain visual analog scare of 4 or higher Exclusion Criteria: Participants who have * Cognitive impairment * History of aller to Hyaluronic acid or its component * History of knee arthropathy * Concomitant with inflammatory arthritis * Serious comorbidities or bedridden status * Current pregnancy or lactation * Currently use of symptomatic slow acting drugs for osteoarthritis (SYSADOA) * Communication problem
Where this trial is running
Bangkok
- Phramongkutklao Hospital — Bangkok, Thailand (Recruiting)
Study contacts
- Principal investigator: Nis Okuma, Medical — Phramongkutklao College of Medicine and Hospital
- Study coordinator: Nis Okuma, Medical
- Email: nitzumo@gmail.com
- Phone: 669-24759900
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.