Comparing hyaluronic acid and corticosteroid injections for shoulder tendinitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicentric, randomized study aims to evaluate the effectiveness of combining hyaluronic acid injections with corticosteroid injections compared to corticosteroid injections alone in patients suffering from supraspinatus tendinopathy. Participants will be assessed for pain relief at three months, with clinical evaluations conducted at one, three, and six months post-treatment. The study targets individuals who have experienced pain for at least two months and have not responded to standard medical treatments. The goal is to determine if the addition of hyaluronic acid can enhance pain management outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Active patient aged between 18 and 65;
* Patient suffering from pain compatible with supraspinatus tendinopathy for at least 2 months;
* Patient with simple tendinopathy or partial tendon rupture;
* Patient with tendinopathy confirmed by ultrasound or MRI;
* Patient with an active pain visual analog scale ≥ 4 for more than 6 weeks;
* Patient with an active pain visual analog scale ≥ 4 on the day of inclusion;
* Patient failing medical treatment (rest, analgesics, NSAIDs, physiotherapy);
* Patient able to follow the protocol and having given oral informed consent to take part in the research;
* Patient affiliated to the social security system or entitled person;

Exclusion Criteria:

* Patient suffering from a transfixing tendon rupture;
* Patients suffering from post-traumatic tendon rupture;
* Patients suffering from calcific tendinopathy (calcification \> 5 mm);
* Patients with associated glenohumeral osteoarthritis;
* Patients with associated symptomatic acromioclavicular osteoarthritis;
* Patients with shoulder pain for reasons other than tendinopathy (capsulitis, chronic inflammatory rheumatism, fibromyalgia, amyloidosis);
* Patients who have had a subacromial infiltration in the previous 6 months;
* Patients with a known allergy to one of the products including their excipients (methyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl alcohol);
* Patients with a known allergy to lidocaine;
* Patients with a local or generalised infection, or suspected infection;
* Patients with severe coagulation disorders or taking anticoagulants;
* Patients with severe and/or uncontrolled hypertension \> 160/100 mmHg;
* Patients with unbalanced diabetes (last HbA1c \> 8.5%);
* Patients with a history of addiction to psychoactive substances;
* Patient participating in another clinical research protocol with an impact on the research objectives;
* Patient already randomised in the study;
* Patient who is pregnant, parturient, breastfeeding or able to procreate without effective contraception\* in the month prior to inclusion and up to 15 days after infiltration;
* Patients under guardianship, curators or deprived of liberty;
* Patient under a mandate for future protection activated ;
* Patient under family guardianship ;
* Patient under court protection ;

Where it's running

• CHD Vendée
  La Roche-sur-Yon, France Recruiting
• CHU Nantes
  Nantes, France Recruiting

Study contacts

• Principal investigator: Céline COZIC, Dr — Centre Hospitalier Départemental Vendée
• Study coordinator: Laura SOULARD
• Email: laura.soulard@ght85.fr
• Phone: 0251080582

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Electroacupuncture with vacuum cupping for shoulder tendinitis

  This study will test whether adding vacuum cupping to electroacupuncture reduces pain and improves shoulder movement in adults (18–70) with rotator cuff or long-head-of-biceps tendinitis and moderate pain.

  Recruiting at 2 sites University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City and 1 other locations · NCT07545785

• Ultrasound-Guided Shock Wave Therapy for Calcific Tendinitis of the Shoulder

  This test is checking whether ultrasound-guided extracorporeal shock wave therapy can help people with calcific tendinitis of the shoulder feel less pain and regain function.

  Recruiting Taipei Medical University WanFang Hospital · Taipei, Taipei · NCT07756307

• MRI-based classification of shoulder calcific deposits to guide treatment

  This study will try a new MRI-based way to classify calcific shoulder deposits to see if deposit location relates to treatment choices for patients who had surgery for calcific tendinitis.

  Recruiting Koç University · Istanbul, Zeytinburnu · NCT07409818

• Using Doppler Ultrasound to Treat Calcified Tendinitis

  This study is testing if using Doppler ultrasound can help people with painful calcium deposits in their shoulder feel better and move more easily.

  Recruiting Taipei Medical University Shuang Ho Hospital · Taipei · NCT06503302

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.