Comparing how healthy and obese individuals respond after eating
Comparative Analysis of Postprandial Effects in Healthy and Obese Individuals
This study tests how healthy people and those with obesity react to a high-fat meal to see if it affects their blood and inflammation differently.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 32 (estimated) |
| Ages | 25 Years and up |
| Sex | All |
| Sponsor | University of Hohenheim Academic / other |
| Locations | 1 site (Stuttgart, Baden-Württemberg) |
| Trial ID | NCT06645756 on ClinicalTrials.gov |
What this trial studies
This study investigates the postprandial effects of a test meal on blood composition and inflammation in healthy individuals versus those with obesity. It focuses on how high-fat diets influence leukocyte activation and the release of pro-inflammatory cytokines, particularly in relation to lipopolysaccharides (LPS). By analyzing the serum metabolome and immune responses, the study aims to understand the chronic inflammation often seen in obese individuals and its implications for health. Participants will be monitored after consuming a test meal to assess these effects.
Who should consider this trial
Good fit: Ideal candidates include adults aged 25 and older with a BMI between 20-25 kg/m2 or 30-40 kg/m2 who can provide informed consent.
Not a fit: Patients with conditions such as diabetes, cardiovascular diseases, or those taking certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into managing postprandial inflammation in obese individuals, potentially improving their overall health outcomes.
How similar studies have performed: While the specific approach of this study may be novel, previous studies have indicated that understanding postprandial responses can lead to significant insights in obesity and inflammation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed declaration of consent * from 25 years of age * BMI 20 kg/m2 - 25 kg/m2 or BMI 30 kg/m2 - 40 kg/m2 * Good venous conditions for blood collection * Sufficient understanding of the German language and sufficient mental state to understand information and instructions related to the study Exclusion Criteria: * Nicotine consumption * High-risk alcohol consumption (more than one standard glass per day for women, more than two standard glasses per day for men) * Antibiotic intake * Taking probiotics, prebiotics and synbiotics, unless taken for more than 90 days * Taking statins or other lipid-lowering medications (e.g., ezetimibe, fibrates) * Taking oral antidiabetics * Taking antacids * Manifest diabetes mellitus * Acute/unstable cardiovascular diseases * Acute inflammatory diseases * autoimmune diseases * kidney diseases * food allergy or food intolerance to food components of the test meal (e.g. eggs) * celiac disease * Pregnancy and lactation * Inability to consume the test meal orally * Placement in a clinic or similar facility due to official or court order (medical history) * Participation in another clinical study (current or within the last 30 days prior to study entry) * A medical condition or regular medication use that, at the investigator's discretion, does not permit study participation or evaluation of study parameters or consumption of the investigational product (individual decision)
Where this trial is running
Stuttgart, Baden-Württemberg
- Metabolic Unit der Universität Hohenheim — Stuttgart, Baden-Württemberg, Germany (Recruiting)
Study contacts
- Principal investigator: Stephan C. Bischoff, Professor — University of Hohenheim
- Study coordinator: Anna Schweinlin
- Email: cape-studie@uni-hohenheim.de
- Phone: +4971145924894
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.