Comparing holmium and thulium laser prostate enucleation for enlarged prostate

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Men with bothersome BPH and prostate volume >40 mL who require surgical enucleation are randomized to receive either Holmium Laser Enucleation of the Prostate (HoLEP) or pulsed Thulium Laser Enucleation of the Prostate (ThuLEP) at LMU Klinikum. The primary outcome is change in International Prostate Symptom Score (IPSS) from baseline to 12 months, with secondary outcomes including urinary flow (Qmax), post-void residual, continence (ICIQ-SF), erectile function (IIEF), and perioperative metrics such as operative time, blood loss, and catheter time. Follow-up visits collect both objective measures and patient-reported outcomes to evaluate functional recovery and complications. The comparison aims to determine whether ThuLEP's pulsed thulium energy offers advantages in precision or hemostasis over the established HoLEP technique.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male, age ≥ 18 years
* Clinically relevant benign prostatic syndrome (BPS) with an established indication for surgical treatment
* International Prostate Symptom Score (IPSS) ≥ 8
* Prostate volume \> 40 ml
* Signed written informed consent

Exclusion Criteria:

* Proven or suspected prostate cancer
* Previous surgery of the prostate or urethra
* Neurogenic bladder dysfunction
* Anticoagulation therapy that cannot be paused perioperatively

Where it's running

• Urologische Klinik und Poliklinik, LMU Klinikum
  Munich, Bavaria, Germany Recruiting

Study contacts

• Study coordinator: Yannic Volz, PD Dr. med.
• Email: yannic.volz@med.uni-muenchen.de
• Phone: +498944000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.