Comparing high-intensity and moderate-intensity exercise for stroke recovery
Exercise Intensity Matters: An Opportunity to Promote Neurorecovery and Cardiovascular Health in Stroke
This study is testing whether high-intensity or moderate-intensity exercise helps stroke survivors recover better and improve their movement skills over 12 weeks.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | McGill University Academic / other |
| Locations | 2 sites (Hamilton, Ontario and 1 other locations) |
| Trial ID | NCT03614585 on ClinicalTrials.gov |
What this trial studies
This multi-site project aims to compare the effects of 12 weeks of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on brain plasticity and cardiovascular health in stroke survivors. Participants will engage in a whole-body exercise program using a recumbent stepper, with assessments conducted at baseline, after the intervention, and at an 8-week follow-up. The study seeks to determine which exercise intensity is more effective in promoting recovery and improving motor function in individuals post-stroke. Additionally, it will evaluate the motivational aspects of HIIT for sustaining long-term exercise participation.
Who should consider this trial
Good fit: Ideal candidates are individuals who have experienced their first-ever stroke 6 to 60 months prior and can walk independently for at least 10 meters.
Not a fit: Patients with significant disabilities, other neurological conditions, or those currently engaged in rehabilitation services may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective rehabilitation strategies that enhance recovery and quality of life for stroke survivors.
How similar studies have performed: Previous studies have shown promising results for high-intensity exercise in stroke rehabilitation, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 6-60 months following first-ever, single stroke confirmed by MRI/CT * Living in the community and able to independently walk at least 10 meters (assistive devices permitted, as this is representative of many people who regain some walking ability following stroke but commonly with some adaptation) * Montreal Cognitive Assessment score \>20 (individuals with this score are capable to follow exercise instructions) Exclusion Criteria: * Significant disability as determined by modified Rankin scale score \<2 * Stroke of non-cardiogenic origin or tumor * Actively engaged in stroke rehabilitation services or a structured exercise program besides the one provided in the study * Class C or D American Heart Association Risk Criteria * Other neurological or musculoskeletal co-morbidities that preclude exercise participation * Pain which is worsened with exercise * Cognitive, communication, or behavioral issues that would limit safe exercise participation * Contraindications to transcranial magnetic stimulation.
Where this trial is running
Hamilton, Ontario and 1 other locations
- Ontario Central South Stroke Network — Hamilton, Ontario, Canada (Recruiting)
- Jewish Rehabiliation Hospital — Laval, Quebec, Canada (Recruiting)
Study contacts
- Principal investigator: Marc Roig, PhD — McGill University
- Study coordinator: Marc Roig, PhD
- Email: marc.roigpull@mcgill.ca
- Phone: 514-398-4400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.