Comparing high-flow nasal cannula to standard nasal cannula during EBUS bronchoscopy
HFNC Versus Conventional Nasal Cannula During EBUS Procedure: a Randomised Controlled Trial
This study tests if using a high-flow nasal cannula instead of a standard one helps adult patients get better oxygen during an endobronchial ultrasound bronchoscopy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | The University Clinic of Pulmonary and Allergic Diseases Golnik Academic / other |
| Drugs / interventions | cart |
| Locations | 4 sites (Zagreb, City of Zagreb and 3 other locations) |
| Trial ID | NCT06637280 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of high-flow nasal cannula compared to standard nasal cannula in preventing oxygen desaturation during endobronchial ultrasound (EBUS) bronchoscopy. Adult patients undergoing the procedure will be randomly assigned to receive either high-flow or standard oxygen supplementation. The primary objective is to determine if the high-flow method provides better oxygenation and reduces the risk of hypoxemia during the bronchoscopy. Both groups will undergo the same bronchoscopy procedure, with the only difference being the method of oxygen delivery.
Who should consider this trial
Good fit: Ideal candidates include adult patients over 18 years old with normal pre-procedural oxygen and carbon dioxide levels who are scheduled for EBUS bronchoscopy.
Not a fit: Patients who may not benefit include those with contraindications for bronchoscopy or high-flow nasal cannula, such as pregnancy or nasopharyngeal obstruction.
Why it matters
Potential benefit: If successful, this study could lead to improved oxygenation and safety for patients undergoing EBUS bronchoscopy.
How similar studies have performed: Other studies have shown promising results with high-flow nasal cannula in various settings, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients older than 18 years, ASA I - III, with normal pre-procedural pO2 (\> 8.0 kPa) and pCO2 (\< 6.7 kPa) levels without oxygen supplementation Exclusion Criteria: * \- Patient refuses to participate in the study * Contraindication for topical anesthesia, iv sedation, or bronchoscopy * Pregnancy * Contraindication for HFNC including nasopharyngeal obstruction and blockage * Patient unable to tolerate HFNC 60l/min (tested before the procedure) * Procedure shorter than 10 min * Less than 3 EBUS-TBNAs performed
Where this trial is running
Zagreb, City of Zagreb and 3 other locations
- University Hospital Centre Zagreb - Jordanovac — Zagreb, City of Zagreb, Croatia (Recruiting)
- National and Kapodistrian University of Athens — Athens, Athens, Greece (Recruiting)
- Clinica Universitaria de Pneumologia, Hospital de Santa Maria — Lisbon, Lisbon District, Portugal (Recruiting)
- University Clinic Golnik — Golnik, Golnik, Slovenia (Recruiting)
Study contacts
- Study coordinator: Ales Rozman, MD, PhD
- Email: ales.rozman@klinika-golnik.si
- Phone: +38641313811
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.