Comparing high and low-frequency high-intensity training for stroke recovery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to explore how the frequency of high-intensity gait training affects locomotor outcomes in individuals who have experienced a stroke. Participants will be randomly assigned to either a high-frequency training group, receiving 18 sessions over 6 weeks, or a low-frequency group, receiving the same training over 12 weeks. The study will assess outcomes at 6, 12, and 24 weeks post-training to determine the effectiveness of each approach. The focus is on improving gait and overall community mobility through structured rehabilitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Unilateral deficits following stroke \> 6 months prior; however individuals \> 4 months post-stroke are eligible for consenting, but final eligibility and potential enrollment will not occur until \> 6 months
* Age 18-85
* Weight \< 350 pounds
* Able to follow 3-step commands
* Able to ambulate with self-selected gait speeds between 0.10-1.0 m/s without physical assistance, but with below knee bracing and/or assistive device as needed
* Lower extremity Fugl-Meyer \< 34
* Medical clearance to participate

Exclusion Criteria:

* Evidence of cerebellar ataxia
* Uncontrolled cardiopulmonary or metabolic disease that limits exercise participation, active heterotopic ossification, recurrent history of lower extremity fractures, previous orthopedic or other peripheral or central neurologic injury that may impair locomotor activities such that, in the judgement of the PI, could compromise the safety of the participant, limit the ability to complete the study, or compromise the objectives of the study.
* Currently participating in other physical therapy
* \>50 units of Botox in the lower extremity OR in the lower extremity, but above the knee if the participant wears an ankle-foot-orthosis (AFO) within the past three months

Where it's running

• Rehabilitation Hospital of Indiana
  Indianapolis, Indiana, United States Recruiting

Study contacts

• Principal investigator: Thomas G Hornby, PhD — Indiana University
• Study coordinator: Christopher Henderson, PhD
• Email: henderce@iu.edu
• Phone: 317-329-2353

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.