Comparing high and low doses of Propofol during anesthesia induction
Hemodynamic Effects of a High Dose Versus Low Dose Propofol During Induction of Anesthesia. a Randomized Comparative Trial.
This study tests whether using high or low doses of Propofol during anesthesia induction affects blood pressure in healthy adults aged 21 to 40.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 21 Years to 40 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo, Abbaseya) |
| Trial ID | NCT06651749 on ClinicalTrials.gov |
What this trial studies
This study investigates the hemodynamic effects of administering high versus low doses of Propofol during the induction phase of anesthesia. Patients aged 21 to 40 years with ASA classifications I and II will be monitored for changes in mean arterial blood pressure at various intervals after Propofol administration. The study will involve careful preoperative assessments and standardized monitoring techniques to ensure accurate data collection. The goal is to determine the optimal dosage that minimizes hemodynamic instability during anesthesia induction.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 21 to 40 years undergoing elective surgery with ASA classifications I and II.
Not a fit: Patients with significant comorbidities, such as severe hypertension or heart disease, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthesia practices that enhance patient safety and stability during surgery.
How similar studies have performed: Previous studies have explored the effects of Propofol on hemodynamics, indicating that dosage can significantly impact patient outcomes, making this approach both relevant and tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age: from 21 years old till 40 years old. 2. Patients with ASA classification I and II. 3. Undergoing a scheduled elective surgery. Exclusion Criteria: 1. Declining to give written informed consent. 2. ASA classification III-V. 3. Patients with class III (morbid) obesity or more (BMI \>40 Kg/m2) 4. Patients with severe intraoperative hypotension requiring large volume of intravascular fluid treatment. 5. Severe or uncontrolled hypertension (NIBP\> 150/100) , congestive heart failure, moderate to severe valvular heart disease , uncontrolled arrhythmia , heart rate\>100bpm . 6. Significant hepatic or renal disorder. 7. Patients with uncontrolled diabetes mellitus type 1 or type 2(evidenced by autonomic dysfunction or organ complications, ischemic heart disease or cerebrovascular disease). 8. Patients who were pregnant (positive pregnancy test) or menstruating. 9. Anemia with hemoglobin level \<9.0 g/dL 10. Hypersensitivity to soybean oil, egg lecithin, or glycerol. 11. Medical substance abuse.
Where this trial is running
Cairo, Abbaseya
- Ain Shams university — Cairo, Abbaseya, Egypt (Recruiting)
Study contacts
- Principal investigator: Hadeer S Saied, M.B.B.CH — Ain Shams University
- Study coordinator: Hadeer S Saied, MBBCH
- Email: hadeer.saad@med.asu.edu.eg
- Phone: +201021588208
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.