Comparing hemodialysis techniques for removing toxins in chronic kidney failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effectiveness of different hemodialysis techniques in removing uremic toxins from patients with chronic end-stage renal disease. It compares the Theranova 400™ filter used in expanded hemodialysis (HDx) with high-flux hemodialysis (HF HD), online hemodiafiltration (OL-HDF), and high-flux hemodiafiltration (HFR). The study will analyze data from approximately 50 patients treated over a four-year period, focusing on mid-term outcomes and the potential benefits of personalized therapy for frail patients. The study is non-interventional, relying on standard clinical practices and existing patient data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Chronic hemodialytic treatment (on dialysis for at least 6 months), hemodialytic treatment with MCO filter (Theranova) or HF filter, OL- HDF or HFR with HFR filter17.
* Continuous use of the same filter for at least 12 months.
* Diuresis \< 200 ml/day.
* Trisweekly hemodialysis treatment.
* Session duration ≥ 210 minutes.
* Availability of clinical data collected during the follow-up that took place at the O.U. of Nephrology, Dialysis and Transplantation - La Manna

Exclusion Criteria:

* Intradialytic hypotension
* Need for dialysis without heparin
* Active bleeding
* Active hematologic diseases
* Thrombocytopenia
* Chronic hepatopathies
* Active systemic inflammatory diseases
* Uncontrolled diabetes mellitus
* Temporary vascular access
* Recurrent vascular access infections

Where it's running

• IRCCS AOU di Bologna Policlinico di Sant'Orsola
  Bologna, Emilia-Romagna, Italy Recruiting

Study contacts

• Principal investigator: Gaetano La Manna, MD — IRCCS AOU di Bologna
• Study coordinator: Marcello Demetri, Biology
• Email: marcello.demetri2@unibo.it
• Phone: +393349549878

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.