Comparing heart rate variability measured on the chest versus the arms during vagus nerve stimulation
Official title: Comparison of Heart Rate Variability Measurement on the Arm and Chest in Transcutaneous Auricular Vagus Nerve Stimulation
Run by Bahçeşehir University · NCT07000175 · Data updated 2026-11-12
This trial tests whether heart rate variability readings differ when measured on the chest, right arm, or left arm in healthy adults during bilateral transcutaneous vagus nerve stimulation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 39 (estimated) |
| Sponsor | Bahçeşehir University Academic / other |
| Locations | 1 site (Trabzon, Ortahisar) |
| Status | Recruiting |
| Started | May 30, 2025 |
| Main results expected | January 30, 2026 |
| Study ends | February 15, 2026 |
| Registry record updated | July 14, 2025 |
| Trial ID | NCT07000175 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults (about 18–45 years old) who can read and write Turkish, have no acute or chronic disease, do not smoke or regularly use alcohol, are not on regular medications, and have no prior neuromodulation exposure are ideal candidates.
✕Probably not a fit
People with acute or chronic medical conditions, smokers or regular alcohol users, those taking regular medications, individuals with prior neuromodulation, or those seeking therapeutic benefit are unlikely to gain benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Healthy participants aged about 18–45 are randomized into three groups to receive a single 20-minute session of bilateral transcutaneous auricular vagus nerve stimulation with identical stimulation settings. Heart rate variability (HRV) will be recorded before and after stimulation from the chest in one group, the right arm in a second group, and the left arm in a third group. Time-domain and frequency-domain HRV parameters will be compared between groups to determine site-related differences in measurement. The protocol excludes people with acute or chronic disease, smokers or regular alcohol users, those on regular medication, and anyone with prior neuromodulation exposure.
Why it matters
Potential benefit: If successful, the results could identify the most reliable measurement site for HRV during tVNS and improve consistency of physiological monitoring across research and clinical settings.
How similar studies have gone: Previous research shows transcutaneous vagus nerve stimulation can change HRV, but direct comparisons of HRV recording locations (chest versus right or left arm) are limited and relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older * To know how to read and write Turkish * Not having any acute or chronic disease Exclusion Criteria: * Previous application of any neuromodulation method * Smoking or alcohol use * Use of any supplementary medication
Where it's running
-
Avrasya University Physical Therapy Laboratory
Trabzon, Ortahisar, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Alper Percin, Ph.D.
- Email: alperpercin@avrasya.edu.tr
- Phone: +905452557585
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.