Comparing heart injury risks in different surgeries for abdominal aortic aneurysm
Treatment With Endovascular or Open Repair for AAA - Comparison of Perioperative Myocardial Injury Detected With Holter-ECG and Troponin
This study is trying to see if patients with abdominal aortic aneurysms have a higher risk of heart injury after open surgery compared to a less invasive endovascular surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Göteborg University Academic / other |
| Locations | 1 site (Gothenburg) |
| Trial ID | NCT04292652 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare the incidence of myocardial injury in patients undergoing elective open surgery versus endovascular surgery for abdominal aortic aneurysm (AAA). It will utilize troponin T levels and a 48-hour Holter ECG to detect subclinical ischemic myocardial injury. The study seeks to understand the cardiovascular risks associated with both surgical techniques, given that myocardial infarction is a leading cause of mortality in AAA surgeries. By analyzing these outcomes, the research hopes to provide insights into safer surgical options for patients.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for elective AAA surgery who meet the inclusion criteria.
Not a fit: Patients with high anesthesiological risk or severe pre-existing cardiac or renal conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical strategies that minimize cardiac complications in AAA patients.
How similar studies have performed: Previous studies have indicated a high incidence of myocardial injury in similar surgical contexts, suggesting that this approach is built on established findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Accepted for AAA surgery of either one of the operative techniques Exclusion Criteria: * High anesthesiological risk * Preoperative cardiac condition with EF \< 25 or ischemic signs on preoperative evaluation * Severe renal insufficiency with s-creatinine \>200
Where this trial is running
Gothenburg
- Gothenburg university — Gothenburg, Sweden (Recruiting)
Study contacts
- Principal investigator: Per Skoog, MD, PhD — Göteborg University
- Study coordinator: Ulf Nilsson, PhD
- Email: ulf.nilsson@gu.se
- Phone: +46317860000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.