Comparing guided and spontaneous bone regeneration for maxillary cyst removal
Radiographic and Histological Assessment of Guided Bone Regeneration Using Deproteinized Bovine Bone Compared to Spontaneous Bone Regeneration of Maxillary Defects , Resulted from Enucleation of Intra-bony Cystic Lesions : Randomized Control Clinical Trial
This study is testing whether a special bone treatment helps people heal better after having cysts removed from their upper jaw compared to letting their body heal on its own.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 44 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Cairo, Giza) |
| Trial ID | NCT06749158 on ClinicalTrials.gov |
What this trial studies
This clinical trial involves two groups of patients with maxillary defects caused by the removal of intra-bony cystic lesions. One group will undergo guided bone regeneration (GBR) using deproteinized bovine bone, while the other will rely on spontaneous bone regeneration. Pre-operative preparations include periodontal therapy and endodontic treatment, followed by a standardized surgical procedure to enucleate the lesions. The study aims to assess the effectiveness of GBR compared to natural healing processes in these patients.
Who should consider this trial
Good fit: Ideal candidates are patients aged 20-50 with maxillary intra-bony defects suitable for implant placement.
Not a fit: Patients with systemic conditions affecting bone healing or those with active infections at the surgical site may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve surgical outcomes and healing processes for patients with maxillary cysts.
How similar studies have performed: Previous studies have shown promising results for guided bone regeneration techniques, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pathological Maxillary intra-bony defects with diameter ranging from 1.5 to 4.0 cm. * patients indicated for implant placement after teeth extraction. * Age range from 20-50 years. * Patients free from any systemic conditions and bone metabolism diseases that might interfere with the surgical intervention, soft tissue or hard tissue healing. * No evidence of acute inflammation. * Regular attendance at control visits. Exclusion Criteria: * Pregnancy or lactation. * Systemic conditions that compromise bone healing such as : uncontrolled diabetes mellitus, history of chemotherapy or radiotherapy or Hematological disorders. * Patients taking bisphosphonates, glucocorticoids or other drugs that may interfere with bone metabolism. * presence of infection at the surgical site. * infected cysts and odontogenic keratocyst.
Where this trial is running
Cairo, Giza
- faculty of oral and dental medicine, Cairo university — Cairo, Giza, Egypt (Recruiting)
Study contacts
- Study coordinator: Alaa M Abdelzaher, BSc
- Email: alaa_mohamed@dentistry.cu.edu.eg
- Phone: +201124716475
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.