Comparing Grape Seed Extract and Laser Therapy for Tooth Sensitivity
Comparison of the Effectiveness of Grape Seed Extract (GSE) and Low-level Laser Therapy in the Management of Dentin Hypersensitivity: A Randomized Control Trial
NA · Manipal University College Malaysia · NCT05927831
This study is testing whether grape seed extract or laser therapy works better to help adults with sensitive teeth feel less pain.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | All |
| Sponsor | Manipal University College Malaysia (other) |
| Locations | 1 site (Melaka Tengah, Melaka) |
| Trial ID | NCT05927831 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of grape seed extract versus low-level laser therapy in treating dentin hypersensitivity, a common dental issue characterized by sharp pain in response to stimuli. Participants will include systemically healthy adults aged 20-50 with at least three sensitive teeth. The study aims to determine which treatment is more effective in reducing sensitivity by either sealing dentinal tubules with laser heat or utilizing the collagen-enhancing properties of grape seed extract. The outcomes will be measured using a visual analog scale (VAS) for pain assessment.
Who should consider this trial
Good fit: Ideal candidates are systemically healthy adults aged 20-50 with at least three sensitive teeth due to gingival recession or tooth wear.
Not a fit: Patients with dental issues such as caries, cracked teeth, or systemic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new effective treatment option for patients suffering from dentin hypersensitivity.
How similar studies have performed: While there is limited data on the specific combination of these treatments, similar studies on laser therapy for dentin hypersensitivity have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with at least three sensitive tooth by gingival recession or tooth wear \>2 scores on the VAS scale. * Tooth wear index score \<3 (Smith and Knight tooth wear index) * Systemically healthy patient. * 20-50 years of age. Exclusion Criteria: * Teeth with caries, cracked teeth, mobile teeth and pulpitis. * Deep periodontal pockets (probing depth \>6 mm), periodontal surgery within the previous 3 months. * Recent desensitizing therapy * systemic diseases and gastric diseases (GERD) * Allergy to active ingredients.
Where this trial is running
Melaka Tengah, Melaka
- Manipal University College Malaysia — Melaka Tengah, Melaka, Malaysia (RECRUITING)
Study contacts
- Principal investigator: Tun Yi Darren Ong — Manipal University College Malaysia
- Study coordinator: Anchu R Thomas
- Email: rachel.thomas@manipal.edu.my
- Phone: +601127292297
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Dentin Hypersensitivity