Clinical trial Recruiting at 4 sites Interventional Ages 18 and up

Comparing generalist and specialist treatments for severe personality disorders

Official title: The (Cost-)Effectiveness of Generalist (GIT-PD) Versus Specialist Treatment (MBT/ST) for Severe Personality Disorders (the P-DAET Study): a Pragmatic Randomized Controlled Non-Inferiority Trial.'

Run by Arkin · NCT06789380 · Data updated 2026-11-12

This study is testing whether a general treatment approach is just as helpful as specialized therapy for people with severe personality disorders.

More Borderline Personality Disorder trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment358 (estimated)
SponsorArkin
Industry-sponsored
Locations5 sites (Halsteren, North Brabant and 4 other locations)
StatusRecruiting
StartedOctober 21, 2024
Main results expectedDecember 2028
Study endsDecember 2028
Registry record updatedFebruary 5, 2025
Trial IDNCT06789380 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals diagnosed with severe or extreme personality disorders according to the alternative model for personality disorders.

Probably not a fit

Patients with an IQ below 75, legal incapacity, or those requiring prior treatment for any mental state disorder may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates whether generalist treatment (GIT-PD) is as effective as specialist treatment (Mentalization-Based Treatment and Schema Therapy) in improving personality functioning in patients with severe personality disorders. Participants will be randomly assigned to receive either generalist or specialist treatment. The study also aims to identify patient characteristics that predict which treatment may be more beneficial for individual patients.

Why it matters

Potential benefit: If successful, this study could provide insights into more effective treatment options for patients with severe personality disorders.

How similar studies have gone: Other studies have explored the effectiveness of generalist versus specialist treatments, but this specific comparison is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 'severe' or 'extreme' personality disorder (PD) according to the alternative model for PDs

Exclusion Criteria:

* IQ \< 75
* legal incapacity
* Any mental state disorder that requires prior treatment

Where it's running

  • GGZ de Viersprong
    Halsteren, North Brabant, Netherlands
    Recruiting
  • GGZ Oost-Brabant
    Helmond, North Brabant, Netherlands
    Recruiting
  • Arkin NPI
    Amsterdam, North Holland, Netherlands
    Recruiting
  • Dimence Group
    Almelo, Overijssel, Netherlands
    Recruiting
  • Altrecht
    Zeist, Utrecht, Netherlands
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Browse more
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.