Comparing generalist and specialist treatments for severe personality disorders
Official title: The (Cost-)Effectiveness of Generalist (GIT-PD) Versus Specialist Treatment (MBT/ST) for Severe Personality Disorders (the P-DAET Study): a Pragmatic Randomized Controlled Non-Inferiority Trial.'
Run by Arkin · NCT06789380 · Data updated 2026-11-12
This study is testing whether a general treatment approach is just as helpful as specialized therapy for people with severe personality disorders.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 358 (estimated) |
| Sponsor | Arkin Industry-sponsored |
| Locations | 5 sites (Halsteren, North Brabant and 4 other locations) |
| Status | Recruiting |
| Started | October 21, 2024 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | February 5, 2025 |
| Trial ID | NCT06789380 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with severe or extreme personality disorders according to the alternative model for personality disorders.
✕Probably not a fit
Patients with an IQ below 75, legal incapacity, or those requiring prior treatment for any mental state disorder may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates whether generalist treatment (GIT-PD) is as effective as specialist treatment (Mentalization-Based Treatment and Schema Therapy) in improving personality functioning in patients with severe personality disorders. Participants will be randomly assigned to receive either generalist or specialist treatment. The study also aims to identify patient characteristics that predict which treatment may be more beneficial for individual patients.
Why it matters
Potential benefit: If successful, this study could provide insights into more effective treatment options for patients with severe personality disorders.
How similar studies have gone: Other studies have explored the effectiveness of generalist versus specialist treatments, but this specific comparison is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 'severe' or 'extreme' personality disorder (PD) according to the alternative model for PDs Exclusion Criteria: * IQ \< 75 * legal incapacity * Any mental state disorder that requires prior treatment
Where it's running
-
GGZ de Viersprong
Halsteren, North Brabant, Netherlands Recruiting -
GGZ Oost-Brabant
Helmond, North Brabant, Netherlands Recruiting -
Arkin NPI
Amsterdam, North Holland, Netherlands Recruiting -
Dimence Group
Almelo, Overijssel, Netherlands Recruiting -
Altrecht
Zeist, Utrecht, Netherlands Not yet recruiting
Study contacts
- Principal investigator: Henricus L. Van, Dr. — Arkin NPI
- Study coordinator: Jan Philipp Löffler, MSc
- Email: J.P.Loffler@tilburguniversity.edu
- Phone: +31-020-590-4700
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.