Comparing gemeprost and dinoprostone for treating first trimester miscarriages
Gemeprost Versus Dinoprostone in the Medical Management of First Trimester Miscarriages: a Randomized Controlled Study
This study is testing whether two medications, gemeprost and dinoprostone, can help women who have had a miscarriage in the first trimester clear the uterus more effectively.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 174 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | National University of Malaysia Academic / other |
| Locations | 2 sites (Kuala Lumpur, W.Persekutuan and 1 other locations) |
| Trial ID | NCT05342467 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of two medications, gemeprost and dinoprostone, in the management of first trimester miscarriages. Women diagnosed with missed or incomplete miscarriages will be randomly assigned to receive either gemeprost or dinoprostone as a vaginal pessary. The study will evaluate the outcomes of these treatments in terms of their ability to facilitate the evacuation of the uterus following a miscarriage. By assessing the efficacy and safety of these two interventions, the trial seeks to provide valuable insights into optimal management strategies for early pregnancy loss.
Who should consider this trial
Good fit: Ideal candidates for this study are women diagnosed with missed or incomplete miscarriages during their first trimester.
Not a fit: Patients with conditions such as coagulopathy, suspected ectopic pregnancy, or those who are hemodynamically unstable may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for women experiencing first trimester miscarriages.
How similar studies have performed: Other studies have explored similar approaches in managing miscarriages, but the specific comparison of gemeprost and dinoprostone in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * missed miscarriages * incomplete miscarriages * first trimester Exclusion Criteria: * coagulopathy * Rhesus negative * suspected ectopic pregnancy or pregnancy of unknown location * on anticoagulation drug * septic miscarriages * hemodynamically unstable
Where this trial is running
Kuala Lumpur, W.Persekutuan and 1 other locations
- UKM Medical Center — Kuala Lumpur, W.Persekutuan, Malaysia (Recruiting)
- UKM Medical Centre — Kuala Lumpur, W.Persekutuan, Malaysia (Recruiting)
Study contacts
- Principal investigator: Rahana Abd Rahman — National University of Malaysia
- Study coordinator: Rahana Abd Rahman
- Email: drrahana@ppukm.ukm.edu.my
- Phone: +60122719985
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.