Comparing fractional CO₂ and long‑pulsed 1064‑nm Nd:YAG lasers for skin rejuvenation
Official title: A Comparative Split-Face Study of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser for Skin Rejuvenation Based on Dermal Thickness, Skin Elasticity, Wrinkle Assessment, and Global Aesthetic Improvement Scale Scores
Run by Universitas Padjadjaran · NCT07467954 · Data updated 2026-11-12
This trial will see if fractional CO₂ laser or long‑pulsed 1064‑nm Nd:YAG better improves signs of skin aging in adults aged 30–59 with Glogau II–III.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 59 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | Universitas Padjadjaran Academic / other |
| Locations | 1 site (Bandung, West Java) |
| Status | Recruiting |
| Started | October 14, 2025 |
| Main results expected | March 10, 2026 |
| Study ends | April 16, 2026 |
| Registry record updated | March 12, 2026 |
| Trial ID | NCT07467954 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 30–59 with Glogau scale II–III photoaging who are non‑smokers, not pregnant or breastfeeding, and have not had recent facial cosmetic procedures or contraindicated medications.
✕Probably not a fit
People who are pregnant or breastfeeding, active smokers, have recent facial treatments, active facial inflammation, a history of keloids, allergy to topical lidocaine, or high sun exposure are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults aged 30–59 with moderate photoaging (Glogau II–III) will receive either fractional CO₂ or long‑pulsed 1064‑nm Nd:YAG laser treatment to compare outcomes. Treatments aim to stimulate collagen remodeling and dermal thickening to reduce laxity and wrinkles, with outcomes assessed by clinical appearance and objective skin changes. Key exclusions include recent facial procedures, isotretinoin use, active facial inflammation, pregnancy, heavy sun exposure, smoking, and history of keloids to protect safety and reduce confounding. The single‑center study is conducted at a tertiary hospital in Bandung with scheduled follow‑up visits to monitor response and adverse effects.
Why it matters
Potential benefit: If successful, results could help patients and clinicians choose the laser that gives better wrinkle reduction and skin tightening with acceptable downtime and side effects.
How similar studies have gone: Fractional CO₂ is considered a gold‑standard ablative approach and Nd:YAG has shown benefit as a nonablative option, but direct head‑to‑head comparisons between these two lasers for skin rejuvenation are lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female patients with skin aging classified as Glogau scale II-III * Age 30-59 years. Exclusion Criteria: * Pregnant or breastfeeding women. * Active smokers. * Individuals with high levels of sun exposure. * History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months. * Use of oral isotretinoin within the past six months. * Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks. * Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month. * Presence of active facial skin inflammation. * History of keloid formation. * History of allergy to topical lidocaine anesthesia.
Where it's running
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Hasan Sadikin General Hospital
Bandung, West Java, Indonesia Recruiting
Study contacts
- Principal investigator: Kartika Ruchiatan, M.D. — Faculty of Medicine Universitas Padjadjaran Bandung
- Study coordinator: Ahmad R Ganiem, M.D., Ph.D
- Email: rizalbdg@gmail.com
- Phone: +62 878 2288 3773
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.