Comparing fractional CO₂ and long‑pulsed 1064‑nm Nd:YAG lasers for skin rejuvenation
A Comparative Split-Face Study of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser for Skin Rejuvenation Based on Dermal Thickness, Skin Elasticity, Wrinkle Assessment, and Global Aesthetic Improvement Scale Scores
This trial will see if fractional CO₂ laser or long‑pulsed 1064‑nm Nd:YAG better improves signs of skin aging in adults aged 30–59 with Glogau II–III.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 30 Years to 59 Years |
| Sex | All |
| Sponsor | Universitas Padjadjaran Academic / other |
| Locations | 1 site (Bandung, West Java) |
| Trial ID | NCT07467954 on ClinicalTrials.gov |
What this trial studies
Adults aged 30–59 with moderate photoaging (Glogau II–III) will receive either fractional CO₂ or long‑pulsed 1064‑nm Nd:YAG laser treatment to compare outcomes. Treatments aim to stimulate collagen remodeling and dermal thickening to reduce laxity and wrinkles, with outcomes assessed by clinical appearance and objective skin changes. Key exclusions include recent facial procedures, isotretinoin use, active facial inflammation, pregnancy, heavy sun exposure, smoking, and history of keloids to protect safety and reduce confounding. The single‑center study is conducted at a tertiary hospital in Bandung with scheduled follow‑up visits to monitor response and adverse effects.
Who should consider this trial
Good fit: Ideal candidates are adults 30–59 with Glogau scale II–III photoaging who are non‑smokers, not pregnant or breastfeeding, and have not had recent facial cosmetic procedures or contraindicated medications.
Not a fit: People who are pregnant or breastfeeding, active smokers, have recent facial treatments, active facial inflammation, a history of keloids, allergy to topical lidocaine, or high sun exposure are excluded and unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, results could help patients and clinicians choose the laser that gives better wrinkle reduction and skin tightening with acceptable downtime and side effects.
How similar studies have performed: Fractional CO₂ is considered a gold‑standard ablative approach and Nd:YAG has shown benefit as a nonablative option, but direct head‑to‑head comparisons between these two lasers for skin rejuvenation are lacking.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female patients with skin aging classified as Glogau scale II-III * Age 30-59 years. Exclusion Criteria: * Pregnant or breastfeeding women. * Active smokers. * Individuals with high levels of sun exposure. * History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months. * Use of oral isotretinoin within the past six months. * Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks. * Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month. * Presence of active facial skin inflammation. * History of keloid formation. * History of allergy to topical lidocaine anesthesia.
Where this trial is running
Bandung, West Java
- Hasan Sadikin General Hospital — Bandung, West Java, Indonesia (Recruiting)
Study contacts
- Principal investigator: Kartika Ruchiatan, M.D. — Faculty of Medicine Universitas Padjadjaran Bandung
- Study coordinator: Ahmad R Ganiem, M.D., Ph.D
- Email: rizalbdg@gmail.com
- Phone: +62 878 2288 3773
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.