Comparing four treatments for Helicobacter pylori in Chinese children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of four different treatment regimens for Helicobacter pylori infection in Chinese children, including standard triple therapy, sequential therapy, bismuth quadruple therapy, and concomitant therapy. Eligible participants, aged 6 to 18, will be randomly assigned to one of the treatment groups for a 14-day course. The primary outcome will be the eradication rate of Helicobacter pylori, assessed 4-6 weeks post-treatment, while secondary outcomes will evaluate side effects, influencing factors, and changes in microbiota. The findings are expected to inform new guidelines for diagnosing and treating Helicobacter pylori in pediatric populations in China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* children 6-18 years of age who were referred for upper endoscopy and confirmed to have Hp infection

Exclusion Criteria:

* patients were excluded if they had taken proton pump inhibitors, H2-receptor antagonists or antibiotics in the 4 weeks prior to the study. Patients with known antibiotic allergy,hepatic impairment or kidney failure were also excluded. Patients who received Hp therapy before were also excluded.

Where it's running

• Children's hospital of Fudan university
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Ying Zhou, master
• Email: nnyyhhs@163.com
• Phone: 13917394900

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.