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Comparing fluid resuscitation methods for severe burn injuries

The Acute Burn ResUscitation Multicenter Prospective Trial (ABRUPT2)

Not applicable Interventional American Burn Association · NCT04356859

This study is testing two different ways to give fluids to adults with severe burns to see which method helps them recover better.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment400 (estimated)
Ages18 Years and up
SexAll
SponsorAmerican Burn Association Academic / other
Locations26 sites (Phoenix, Arizona and 25 other locations)
Trial IDNCT04356859 on ClinicalTrials.gov

What this trial studies

This multicenter prospective trial aims to compare two fluid resuscitation strategies in adults with acute burns covering at least 25% of their total body surface area. Participants will be randomly assigned to receive either a colloid strategy (Lactated Ringer's solution plus 5% albumin) or a crystalloid strategy (Lactated Ringer's solution alone). The study will ensure balanced injury severity across groups through block stratification based on age, burn size, and inhalation injury presence. Each group will receive their designated fluids for the first 48 hours post-burn, with adjustments made based on urinary output.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with significant burn injuries covering 25% or more of their body.

Not a fit: Patients with significant associated trauma or specific pre-existing conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve fluid resuscitation protocols for burn patients, potentially leading to better recovery outcomes.

How similar studies have performed: Previous studies have explored fluid resuscitation strategies in burn patients, but this specific comparison of colloid versus crystalloid in a multicenter setting is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age ≥ 18 years
* Total burn size (second and third degree) is ≥ 25% of the TBSA
* Burn center admission within 12 hours of injury.
* There is a plan for formal fluid resuscitation.

Exclusion Criteria:

* Significant associated trauma
* High voltage (≥ 1000 volts) electrical burns
* Burn wound excision surgery within 48 hours from injury
* Fresh frozen plasma (FFP) given at any time ≤ 48 hours from injury
* Hypertonic saline (HTS) given at any time ≤ 48 hours from injury
* Hydroxyethyl starch (HES) given at any time ≤ 48 hours from injury
* High dose Vitamin C infusion given at any time ≤ 48 hours from injury
* Administration of human albumin prior to randomization
* Palliative comfort measures are instituted ≤ 48 hours from injury
* Pregnancy
* Pre-injury chronic renal insufficiency equal to or greater than stage 3
* Pre-injury chronic hepatic disease (Child-Pugh B or C)
* Pre-injury left ventricular (LV) dysfunction (echocardiography LV grade II-IV or ejection fraction ≤ 35%)

Where this trial is running

Phoenix, Arizona and 25 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Burn InjuryResuscitation
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.