Comparing fluid management methods during breast reduction surgery

Comparison of Hemodynamic Results of Two Different Fluid Managements in Reduction Mammoplasty Operation

This study is testing two different ways of managing fluids during breast reduction surgery to see which one helps women stay stable and feel better during the procedure.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years to 65 Years
• Sex: Female
• Sponsor: Istanbul University (Academic / other)
• Locations: 1 site (Istanbul, Fatih)
• Trial ID: NCT05733403 on ClinicalTrials.gov

What this trial studies

This study evaluates two different fluid management strategies during reduction mammoplasty operations to optimize hemodynamic parameters in female patients without co-morbidities. The research focuses on the infusion of crystalloid fluids at a constant rate and the use of dynamic parameters like pulse pressure variation and stroke volume variation to assess intravascular volume. The study also investigates the role of inducible nitric oxide synthetase (iNOS) levels in relation to tissue manipulation during surgery. By monitoring these factors, the aim is to improve patient outcomes and reduce hypotensive episodes during surgery.

Who should consider this trial

Good fit: Ideal candidates for this study are female patients aged between 18 and 65 who are undergoing reduction mammoplasty and have an ASA classification of 1 or 2.

Not a fit: Patients with serious hypertension or those outside the age range of 18 to 65 may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved fluid management protocols that enhance patient safety and recovery during breast reduction surgeries.

How similar studies have performed: Previous studies have shown varying success with fluid management approaches in surgical settings, but this specific evaluation of iNOS levels in relation to fluid management during breast surgery is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Volunteering to participate in the study
2. ASA classification 1 or 2
3. The patients who will undergo reduction mammoplasty operation

Exclusion Criteria:

1. Being under the age of 18 or over the age of 65
2. Presence of serious hypertension

Where this trial is running

Istanbul, Fatih

• Istanbul University, Department of Anesthesiology — Istanbul, Fatih, Turkey (Recruiting)

Study contacts

• Principal investigator: Ceren Yılmaz, Resident — Istanbul University
• Study coordinator: Demet Altun Bingol, Assoc. Prof.

Conditions Perioperative Fluid Management; fluid therapy; hemodynamic parameters; The pulse contour cardiac output system; inducible nitric oxide synthetase