Comparing five extended-depth-of-focus intraocular lenses and one standard monofocal lens for cataract surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, interventional comparison enrolls adults undergoing bilateral cataract surgery who receive one of six intraocular lens (IOL) models implanted in both eyes. The five enhanced-depth-of-focus (EDOF) lenses (TECNIS Eyhance, AcrySof IQ Vivity, LuxSmart, Rayner EMV, Eyecryl SERT) are compared head-to-head against a standard monofocal lens (CT ASPHINA 409M). Outcomes include uncorrected and best-corrected visual acuity at multiple distances, patient-reported satisfaction, and spectacle dependence. Participants must meet ocular health criteria such as regular corneal astigmatism <1.0 D and be within the available IOL power range.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Bilateral implantation of the same intraocular lens (IOL) model
* Expected postoperative best-corrected distance visual acuity (BCDVA) of 0.8 (decimal) or better
* Regular corneal astigmatism less than 1 diopter

Exclusion Criteria:

* Endothelial cell density \< 2,000 cells/mm²
* Required IOL power for emmetropia falls outside the available range of +10.0 D to +30.0 D
* Pupillary abnormalities
* Intraocular inflammation
* Recent ocular trauma or ocular surgery that is unresolved/unstable, or which may impair visual outcomes or increase patient risk
* History of corneal refractive surgery (e.g., LASIK, LASEK, PRK)
* Irregular astigmatism, as well as corneal abnormalities or opacities
* Conditions associated with an increased risk of zonular rupture, including capsular or zonular anomalies that may lead to IOL decentration or tilt, such as pseudoexfoliation syndrome, trauma, Marfan syndrome, among others
* Systemic or ocular diseases, or medications, that may impair vision, increase surgical risk, or confound study outcomes
* Clinically significant dry eye disease affecting visual function
* Anticipated need for retinal laser treatment or any other ocular surgical intervention during the study period
* Pregnancy, planned pregnancy, breastfeeding, or any condition associated with hormonal fluctuations that may induce refractive changes
* Continuous contact lens wear within the past 4 weeks
* Inability to understand and/or complete study questionnaires
* Advanced glaucoma with visual field defects
* Age-related macular degeneration (exudative or geographic form)

Where it's running

• Augenklinik Ahaus
  Ahaus, North Rhine-Westphalia, Germany Recruiting

Study contacts

• Principal investigator: dr. med. (Univ. Bud.) Matthias Gerl, MD — Augenklinik Ahaus
• Study coordinator: dr. med. (Univ. Bud.) Matthias Gerl, MD
• Email: m.gerl@augenklinik.de
• Phone: +49 (2561) 9555-301

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using asymmetrical toric intraocular lenses to improve vision for people with irregular corneas

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• Comparing two trifocal toric intraocular lenses for cataract surgery.

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• Clareon PanOptix versus AcrySof PanOptix for contrast vision after cataract surgery

  This study will try Clareon PanOptix in one eye and AcrySof PanOptix in the other to see which lens gives better contrast vision three months after cataract surgery for adults seeking presbyopia correction.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.