Comparing endometrial preparation methods for frozen embryo transfer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare two different methods of preparing the endometrium for frozen embryo transfer (FET) cycles: mild ovarian stimulation using letrozole versus hormonal replacement therapy (HRT) combined with letrozole. The goal is to determine which method yields better reproductive outcomes, particularly focusing on pregnancy rates and potential complications. Participants will include women aged 18 to 37 with good-quality blastocysts available for transfer. The study will assess the effectiveness of these protocols in synchronizing the embryo stage with the endometrium to optimize pregnancy success.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged between 18 and 37 years with either regular cycles or oligomenorrhoea or amenorrhoea.
* Women undergoing FET cycles.
* Participants should have at least one good-quality blastocyst available for vitrification and also for transfer after warming.
* Participants having optimal endometrium before starting luteal phase support

Exclusion Criteria:

* Women who will refuse to participate in in the study.
* Women who will not reach the optimal endometrium.
* Participants that don't have at least one good-quality blastocyst for transfer after warming.
* PGT embryos will be excluded.

Where it's running

• Rahem fertility center
  Zagazig, Egypt Recruiting

Study contacts

• Principal investigator: Eman El-gindy, MD,PhD — Rahem Fertility Center
• Study coordinator: Noha Moustafa El-hibishy, MSc
• Email: nohaesmaeelobgyn@yahoo.com
• Phone: 00201067411131

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.