Comparing effectiveness of treatments for chronic pain
Integrating Pragmatic Comparative Effectiveness Research Into a Tertiary Pain Management Center
This study is trying to see which treatments for chronic pain work best for different people by tracking their experiences in real-life settings.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 450 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Stanford University Academic / other |
| Locations | 1 site (Redwood City, California) |
| Trial ID | NCT04441034 on ClinicalTrials.gov |
What this trial studies
This study aims to enhance the generalizability of clinical data for chronic pain treatments by integrating pragmatic comparative effectiveness research into patient care. It addresses the limitations of traditional randomized controlled trials, which often exclude a significant portion of patients with comorbidities. By utilizing an open-source learning health care system called CHOIR, the study will track patients' clinical trajectories and treatment responses across multiple sites. The ultimate goal is to develop personalized treatment options based on real-world effectiveness data.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with persistent pain lasting more than three months who are candidates for treatment with anti-convulsants or anti-depressants.
Not a fit: Patients who have contraindications to anti-convulsants or anti-depressants, or those who refuse participation, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment options for patients suffering from chronic pain.
How similar studies have performed: Other studies have shown success with pragmatic approaches in chronic pain management, indicating a promising avenue for this type of research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age of 18 years old or above * Persistent pain for more than 3 months * Candidate for treatment by anti-convulsants or anti-depressants based on treating pain provider * Equipoise between anti-convulsants and anti-depressants according to the treating pain provider Exclusion Criteria: * Contraindication to taking anti-convulsants or anti-depressants: this exclusion is based on the judgement of the treating pain provider; e.g. if the patient is on a large dose of serotonin specific reuptake inhibitor (SSRI) anti-depressant, it will stop the physician from considering any other anti-depressants; thus, excluding the patient * Patient refusal
Where this trial is running
Redwood City, California
- Stanford Pain Management Center — Redwood City, California, United States (Recruiting)
Study contacts
- Study coordinator: Vafi Salmasi, MD
- Email: vsalmasi@stanford.edu
- Phone: 6507250246
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.