Comparing EDTA, chlorhexidine, and essential-oil mouthrinses after a tooth extraction with socket bone graft
A Prospective, Randomized Clinical Trial to Compare Post-extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.
This will test whether EDTA-based mouthrinses work as well as standard 0.12% chlorhexidine and an essential-oil rinse for immediate post-operative and daily use after a single-tooth extraction and ridge-preservation graft.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Trial ID | NCT07191262 on ClinicalTrials.gov |
What this trial studies
This interventional trial compares immediate post-operative and daily use of commercially available EDTA mouthrinses against standard 0.12% chlorhexidine for immediate post-op care and an essential-oil rinse for daily hygiene in adults undergoing single-rooted tooth extraction with simultaneous ridge-preservation bone grafting. Eligible participants who are established patients at the UAB School of Dentistry will be assigned to one of the rinse regimens and followed for 12 weeks to monitor soft-tissue healing and dimensional changes at the extraction site. Outcomes include clinical healing measures, dimensional ridge change, and microbiological or biomarker measures relevant to wound healing. The design aims to see if EDTA offers effective antimicrobial action with less negative impact on local tissue healing compared with broad-spectrum chlorhexidine.
Who should consider this trial
Good fit: Adults aged 18–85 who are established, registered patients at the UAB School of Dentistry and need extraction of a single-rooted tooth with simultaneous ridge-preservation bone grafting, with healthy adjacent teeth and no contraindicating systemic conditions, are ideal candidates.
Not a fit: People who smoke heavily, have systemic conditions that impair wound healing, require multiple adjacent extractions, are not UAB patients, or cannot attend follow-up visits are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, EDTA rinses could provide antimicrobial protection after extraction while reducing cytotoxic effects and supporting better tissue healing compared with standard chlorhexidine.
How similar studies have performed: EDTA has historical use in oral care products and laboratory studies suggest effects on biofilm formation, but clinical comparisons of EDTA rinses versus chlorhexidine for post-extraction healing remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to read and provide informed consent in English * At least 18 years old * Established and registered patient of the UAB School of Dentistry * Patients presenting with one single rooted tooth determined to need extraction and simultaneous ridge preservation bone grafting for future dental implant placement. * Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of the tooth planned for extraction. * No anticipated need for surgical and/or endodontic care at teeth adjacent to the proposed surgical site during the study period. Exclusion Criteria: * Non-English speaking * Age less than 18 years old or older than 85 years old * Smokers/nicotine users (\>10 cigarettes or equivalent/day) * Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing * Multiple adjacent teeth require extraction and grafting * Absence of adjacent teeth/implants on either side of the tooth to be extracted. * Documented or suspected allergy or sensitivity to any study product
Where this trial is running
Birmingham, Alabama
- University of Alabama at Birmingham — Birmingham, Alabama, United States (Recruiting)
Study contacts
- Study coordinator: Maria L Geisinger, DDS, MS
- Email: miagdds@uab.edu
- Phone: 205-934-4984
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.