Comparing early versus delayed oral feeding after surgery for perforated peptic ulcers
Official title: Early Oral Feeding Versus Traditional Delayed Oral Feeding Post-perforated Peptic Ulcer Repair: A Comparative Study in Egyptian Tertiary Health Care Center
Run by Cairo University · NCT06042933 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether starting to eat sooner after surgery for perforated peptic ulcers helps patients recover better than waiting longer to eat.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06042933 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older diagnosed with a perforated duodenal ulcer who are undergoing surgical repair.
✕Probably not a fit
Patients with preoperative refractory septic shock, significant comorbidities, or those presenting late may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the safety and benefits of early oral feeding compared to traditional delayed oral feeding in patients who have undergone surgery for perforated peptic ulcers. It is a single-center, prospective, parallel arm, randomized controlled trial where patients are randomly assigned to either an early feeding protocol starting 12 hours post-surgery or a delayed feeding protocol starting 72 hours post-surgery. The study aims to assess postoperative complications, length of hospital stay, return of bowel function, and diet intolerance as primary outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery times and reduced complications for patients undergoing surgery for perforated peptic ulcers.
How similar studies have gone: Other studies have shown promising results with early oral feeding protocols in similar surgical contexts, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: - All consecutive patients, of age 18 years and above, who were presented to the emergency surgical team and were diagnosed with perforated duodenal ulcer by surgicalteam, were recruited and assessed for eligibility. Exclusion Criteria: * • Preoperative refractory septic shock on admission. * Delayed presentation more than 24 hours. * The presence of neuropsychiatric disease, pregnant and lactating women. * Predisposing factors for impaired wound healing (e.g., currently using immunosuppressive agents, or chronic use of steroids), the presence of HIV. * American society of anesthesiologists grade iii/iv, or had an alternative perioperative diagnosis. * Intraoperatively, after randomization, patients were excluded based on the following criteria: perforated duodenal ulcer ≥20 mm, consistent with malignant ulcers.
Where it's running
-
Cairo University
Cairo, Egypt Recruiting
Study contacts
- Principal investigator: mohammed elshwadfy — Cairo University
- Study coordinator: mohammed elshwadfy
- Email: m.elshwadfy1988@gmail.com
- Phone: 00201025524630
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Gyrotonic exercise for elders with breast cancer and Behcet disease
We’re testing whether a gyrotonic exercise program helps older people who have both Behcet disease and breast cancer.
-
Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft
This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.
-
Virtual Reality and Mental Practice to Improve Balance and Walking in Relapsing MS
This study tests whether virtual reality training or mental practice can improve balance and walking in people with relapsing–remitting multiple sclerosis.
-
Video Microscope vs Loupe-Assist in Varicocelectomy
This study tests whether using a video telescopic operating microscope (VITOM) provides better outcomes and surgeon satisfaction than loupe-assisted varicocelectomy in adult men with grade II/III varicoceles.
-
Isometric Handgrip Training Before and After Heart Surgery to Boost Recovery
This study tests whether gentle handgrip exercise before and after open-heart surgery helps people recover their physical ability and autonomic function.
-
crisaborole 2% versus tacrolimus 0.1% with light therapy for facial vitiligo
This study tests whether applying crisaborole 2% ointment can improve stable facial vitiligo in children and adults and whether it is as safe and effective as tacrolimus 0.1% when combined with light therapy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.