Comparing early versus delayed oral feeding after surgery for perforated peptic ulcers
Early Oral Feeding Versus Traditional Delayed Oral Feeding Post-perforated Peptic Ulcer Repair: A Comparative Study in Egyptian Tertiary Health Care Center
This study is testing whether starting to eat sooner after surgery for perforated peptic ulcers helps patients recover better than waiting longer to eat.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06042933 on ClinicalTrials.gov |
What this trial studies
This study evaluates the safety and benefits of early oral feeding compared to traditional delayed oral feeding in patients who have undergone surgery for perforated peptic ulcers. It is a single-center, prospective, parallel arm, randomized controlled trial where patients are randomly assigned to either an early feeding protocol starting 12 hours post-surgery or a delayed feeding protocol starting 72 hours post-surgery. The study aims to assess postoperative complications, length of hospital stay, return of bowel function, and diet intolerance as primary outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with a perforated duodenal ulcer who are undergoing surgical repair.
Not a fit: Patients with preoperative refractory septic shock, significant comorbidities, or those presenting late may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery times and reduced complications for patients undergoing surgery for perforated peptic ulcers.
How similar studies have performed: Other studies have shown promising results with early oral feeding protocols in similar surgical contexts, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - All consecutive patients, of age 18 years and above, who were presented to the emergency surgical team and were diagnosed with perforated duodenal ulcer by surgicalteam, were recruited and assessed for eligibility. Exclusion Criteria: * • Preoperative refractory septic shock on admission. * Delayed presentation more than 24 hours. * The presence of neuropsychiatric disease, pregnant and lactating women. * Predisposing factors for impaired wound healing (e.g., currently using immunosuppressive agents, or chronic use of steroids), the presence of HIV. * American society of anesthesiologists grade iii/iv, or had an alternative perioperative diagnosis. * Intraoperatively, after randomization, patients were excluded based on the following criteria: perforated duodenal ulcer ≥20 mm, consistent with malignant ulcers.
Where this trial is running
Cairo
- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: mohammed elshwadfy — Cairo University
- Study coordinator: mohammed elshwadfy
- Email: m.elshwadfy1988@gmail.com
- Phone: 00201025524630
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.