Comparing early and standard drainage for fluid collections in pancreatitis
Postponed or Early Drainage of Peripancreatic Fluid Collections: a Randomized Controlled Multicenter Study
This study tests if draining fluid collections early in patients with acute pancreatitis leads to better recovery than waiting for the standard treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT05281458 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of early endoscopic drainage versus standard delayed drainage for peripancreatic fluid collections in patients with acute pancreatitis. Participants will be randomly assigned to either undergo early drainage within one week of symptom onset or to follow the standard protocol of delayed drainage. The study will monitor outcomes over a six-month follow-up period, utilizing imaging techniques to assess the resolution of fluid collections. The goal is to determine if earlier intervention can improve patient outcomes compared to the traditional approach.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients with peripancreatic fluid collections who are admitted within 72 hours of the onset of acute pancreatitis.
Not a fit: Patients who are more than 30 days post-onset of acute pancreatitis or those with chronic pancreatitis will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with acute pancreatitis, potentially reducing complications and mortality rates.
How similar studies have performed: While the approach of early drainage is being evaluated, current guidelines suggest delayed intervention; thus, this study explores a potentially novel approach that has not been widely tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients with PFC; * All patients with PFC will be screened for eligibility including a protocolized approach; * Patients admitted within 72 hours of onset Exclusion Criteria: * More than 30 days after onset of acute pancreatitis * Pregnant women * Documented chronic pancreatitis * Inability to gave informed consent
Where this trial is running
Shanghai, Shanghai
- Shanghai General Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, Shanghai, China (Recruiting)
Study contacts
- Study coordinator: Baiwen Li
- Email: muzibowen@126.com
- Phone: (+86)021-37798977
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.