Comparing early and delayed timing for final oocyte maturation in IVF cycles

Randomized Trial Comparing Early "Trigger" Versus Delayed "Trigger" Timing in Cycles of Controlled Ovarian Stimulation.

This study tests whether giving a medication to mature eggs earlier or later in IVF cycles helps improve egg quality and success rates for people undergoing fertility treatment.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 150 (estimated)
• Ages: 18 Years to 34 Years
• Sex: Female
• Sponsor: Fertility Center of Las Vegas (Industry-sponsored)
• Locations: 1 site (Las Vegas, Nevada)
• Trial ID: NCT05498350 on ClinicalTrials.gov

What this trial studies

This trial investigates the effectiveness of two different timing strategies for administering medications that trigger final oocyte maturation during controlled ovarian stimulation for in vitro fertilization (IVF). Participants will be randomly assigned to receive either an early trigger based on the size of follicles or a delayed trigger when follicles reach a larger size. The study focuses on cycles where all embryos will be cryopreserved, allowing for a comparison of outcomes between the two timing methods. The goal is to determine which timing yields better results in terms of oocyte quality and overall success rates.

Who should consider this trial

Good fit: Ideal candidates are adult females aged 18 to 35 who are planning to undergo IVF with a freeze-all approach and have a normal ovarian response.

Not a fit: Patients with conditions that prevent immediate culture to the blastocyst stage or those deemed at undue risk by the physician may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could optimize IVF protocols, potentially improving outcomes for women undergoing fertility treatments.

How similar studies have performed: While similar approaches have been explored, this specific timing comparison in the context of freeze-all cycles is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Adult female at least 18 years of age and less than 35 years of age intending to undergo ovarian stimulation for a cycle of IVF with all embryos to be frozen that attain the blastocyst stage.
2. Anticipated at least normal ovarian response evidenced by at least 8 antral follicles observed on ultrasound or a serum level of at least 1.5 ng/ml AMH.
3. Ability read and understand English sufficiently to obtain informed consent.
4. Patients with prior IVF cycles are allowed, but no patient can undergo more than one cycle with oocyte collection under this study.

Exclusion Criteria:

1. Any cycle type that would preclude immediate culture to blastocyst stage (e.g. oocyte banking).
2. Any condition that, in the opinion of the physician or principal investigator, would place the patient at undue risk under this protocol or would otherwise make the protocol inappropriate for that subject.

Where this trial is running

Las Vegas, Nevada

• Fertility center of Las Vegas — Las Vegas, Nevada, United States (Recruiting)

Study contacts

• Study coordinator: Forest Garner, MS

Conditions Infertility, Female